UniProt P80183
Tetrahydromethanopterin S-methyltransferase subunit D (P80183)
Tetrahydromethanopterin S-methyltransferase subunit D (UniProt P80183): 2 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 17 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P80183
- Protein
- Tetrahydromethanopterin S-methyltransferase subunit D
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 17 · 2 records with a druggable one
Structures
3 records of P80183 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8Q3V | Cryo-EM structure of the methanogenic Na+ translocating N5-methyl-H4MPT:CoM methyltransferase… | electron microscopy | D, d, T | JCV | 8 (best 0.73) |
| 8Q54 | N5-methyl-H4MPT:CoM methyltransferase -coenzyme M complex + CoM | electron microscopy | D, d, T | JCV | 9 (best 0.72) |
| P80183 | AlphaFold monomer V2.0 prediction for tetrahydromethanopterin S-methyltransferase subunit D (P80183) | predicted | A | — | — |
Ligands
- JCV · [(2~{S},7~{R},11~{R},15~{S},19~{S},22~{S},26~{S},30~{R},34~{R},39~{S},43~{R},47~{R},51~{S},55~{S},58~{S},62~{S},66~{R},70~{R})-39-[[(2~{R},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-7,11,15,19,22,26,30,34,43,47,51,55,58,62,66,70-hexadecamethyl-1,4,37,40-tetraoxacyclodoheptacont-2-yl]methyl [(2~{R},3~{S},5~{R},6~{R})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl] hydrogen phosphate · in 2 records
Experiment against prediction
- 8Q54 chain d against the predicted model P80183: TM-score 0.98, RMSD 1.10 Å
- 8Q3V chain d against the predicted model P80183: TM-score 0.98, RMSD 1.10 Å
- 8Q54 chain T against the predicted model P80183: TM-score 0.98, RMSD 1.10 Å
- 8Q3V chain T against the predicted model P80183: TM-score 0.98, RMSD 1.10 Å
- 8Q3V chain D against the predicted model P80183: TM-score 0.98, RMSD 1.10 Å
- 8Q54 chain D against the predicted model P80183: TM-score 0.98, RMSD 1.10 Å
Elsewhere
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