UniProt P78540
Arginase-2, mitochondrial (P78540)
Arginase-2, mitochondrial (UniProt P78540), EC 3.5.3.1: 26 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 101 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P78540
- Protein
- Arginase-2, mitochondrial
- EC
- 3.5.3.1
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 101 · 9 records with a druggable one
Structures
27 records of P78540 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1PQ3 | Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1PQ3 | Human arginase II: crystal structure and physiological role in male and female sexual arousal | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4HZE | Crystal structure of human Arginase-2 complexed with inhibitor 9 | x-ray diffraction | A, B, C | — | — |
| 4HZE | Crystal structure of human arginase-2 complexed with inhibitor 9 | x-ray diffraction | A, B, C | — | — |
| 4I06 | Crystal structure of human Arginase-2 complexed with inhibitor 14 | x-ray diffraction | A, B, C | — | — |
| 4I06 | Crystal structure of human arginase-2 complexed with inhibitor 14 | x-ray diffraction | A, B, C | — | — |
| 4IE2 | Crystal structure of human Arginase-2 complexed with inhibitor 1h | x-ray diffraction | A, B, C | — | — |
| 4IE2 | Crystal structure of human arginase-2 complexed with inhibitor 1H | x-ray diffraction | A, B, C | — | — |
| 4IE3 | Crystal structure of human Arginase-2 complexed with inhbitor 1o | x-ray diffraction | A, B, C | — | — |
| 4IE3 | Crystal structure of human arginase-2 complexed with inhbitor 1O | x-ray diffraction | A, B, C | — | — |
| 4IXU | Crystal structure of human Arginase-2 complexed with inhibitor 11d… | x-ray diffraction | A, B, C | — | — |
| 4IXU | Crystal structure of human arginase-2 complexed with inhibitor 11D… | x-ray diffraction | A, B, C | — | — |
| 4IXV | Crystal structure of human Arginase-2 complexed with inhibitor 2d… | x-ray diffraction | A, B, C | — | — |
| 4IXV | Crystal structure of human arginase-2 complexed with inhibitor 2D… | x-ray diffraction | A, B, C | — | — |
| 6Q37 | Complex of Arginase 2 with Example 23 | x-ray diffraction | A, B, C | MN, BEN, HE8 | 9 (best 0.80) |
| 6Q37 | Complex of arginase 2 with example 23 | x-ray diffraction | A, B, C | MN, BEN, HE8 | — |
| 6Q39 | Complex of Arginase 2 with Example 49 | x-ray diffraction | A, B, C | MN, BEN, HDQ | 10 (best 0.80) |
| 6Q39 | Complex of arginase 2 with example 49 | x-ray diffraction | A, B, C | MN, BEN, HDQ | — |
| 6SS2 | Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021158 | x-ray diffraction | AAA | MN, SO4 | 5 (best 0.49) |
| 6SS4 | Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021181 | x-ray diffraction | AAA | MN, PO4 | 2 (best 0.57) |
| 6SS6 | Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0020187 | x-ray diffraction | AAA, BBB, CCC | MN, SO4 | 15 (best 0.81) |
| 8RFA | Arginase 2 in complex with an inhibitor | x-ray diffraction | A, B, C | MN, A1HZ9 | 12 (best 0.81) |
| 8RGF | Arginase 2 in complex with inhibitor | x-ray diffraction | A, B, C | MN, A1H0A | 13 (best 0.80) |
| 8RGU | Arginase 2 in complex with inhibitor | x-ray diffraction | A, B, C | MN, PRO | 11 (best 0.80) |
| 8RIM | Arginase 2 in complex with inhibitor | x-ray diffraction | A, B, C | MN, A1H04 | 12 (best 0.80) |
| 9FRV | Arginase 2 in complex with inhibitor | x-ray diffraction | A, B, C | MN, A1IFX | 12 (best 0.81) |
| P78540 | AlphaFold monomer V2.0 prediction for arginase-2, mitochondrial (P78540) | predicted | A | — | — |
Ligands
- MN · Manganese (II) ion · in 12 records
- BEN · Benzamidine · in 4 records
- HDQ · 3-[(3~{S},4~{R})-4-azanyl-4-carboxy-1-[[(2~{S})-piperidin-2-yl]methyl]pyrrolidin-3-yl]propyl-tris(oxidanyl)boranuide · in 2 records
- HE8 · 3-[(3~{S},4~{R})-4-azanyl-4-carboxy-pyrrolidin-3-yl]propyl-tris(oxidanyl)boranuide · in 2 records
- SO4 · Sulfate ion · in 2 records
- A1H04 · [(5~{S})-5-azanyl-4-[[[(2~{S})-2-azanyl-3-methyl-butanoyl]amino]methyl]-6-oxidanyl-6-oxidanylidene-hexyl]-$l^{3}-oxidanyl-bis(oxidanyl)boron · in 1 record
- A1H0A · 4-[(2~{R},4~{R})-4-azanyl-2-carboxy-pyrrolidin-2-yl]butyl-tris(oxidanyl)boranuide · in 1 record
- A1HZ9 · [(4~{R},5~{S})-4-(aminomethyl)-5-azanyl-6-oxidanyl-6-oxidanylidene-hexyl]-tris(oxidanyl)boron · in 1 record
- A1IFX · [(4~{S},5~{S})-4-(aminomethyl)-5-azanyl-6-oxidanyl-6-oxidanylidene-hexyl]-$l^{3}-oxidanyl-bis(oxidanyl)boron · in 1 record
- PO4 · Phosphate ion · in 1 record
- PRO · Proline · in 1 record
Experiment against prediction
- 4IXU chain C against the predicted model P78540: TM-score 1.00, RMSD 0.19 Å
- 4IXU chain C against the predicted model P78540: TM-score 1.00, RMSD 0.19 Å
- 4IE2 chain C against the predicted model P78540: TM-score 1.00, RMSD 0.20 Å
- 4IE2 chain C against the predicted model P78540: TM-score 1.00, RMSD 0.20 Å
- 6Q37 chain C against the predicted model P78540: TM-score 1.00, RMSD 0.20 Å
- 6Q37 chain C against the predicted model P78540: TM-score 1.00, RMSD 0.20 Å
- 4I06 chain C against the predicted model P78540: TM-score 1.00, RMSD 0.21 Å
- 4I06 chain C against the predicted model P78540: TM-score 1.00, RMSD 0.21 Å
- 6Q39 chain C against the predicted model P78540: TM-score 1.00, RMSD 0.21 Å
- 6Q39 chain C against the predicted model P78540: TM-score 1.00, RMSD 0.21 Å
Elsewhere
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