UniProt P76149
Succinate semialdehyde dehydrogenase [NAD(P)+] Sad (P76149)
Succinate semialdehyde dehydrogenase [NAD(P)+] Sad (UniProt P76149), EC 1.2.1.16: 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 40 pockets. Binding sites, druggability and experiment against…
- UniProt
- P76149
- Protein
- Succinate semialdehyde dehydrogenase [NAD(P)+] Sad
- EC
- 1.2.1.16
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 40 · 3 records with a druggable one
Structures
3 records of P76149 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8QMR | Succinic semialdehyde dehydrogenase from E. coli with bound NAD+ and succinic semialdehyde | x-ray diffraction | A, B, C, D | NAD, SSN | 19 (best 0.80) |
| 8QMT | Succinic semialdehyde dehydrogenase from E. coli with Q262R substitution and bound NAD+, succinic… | x-ray diffraction | A, B, C, D | NAD, SSN | 18 (best 0.81) |
| P76149 | AlphaFold monomer V2.0 prediction for succinate semialdehyde dehydrogenase [NAD(P)+] sad (P76149) | predicted | A | — | 3 (best 0.68) |
Ligands
Experiment against prediction
- 8QMT chain A against the predicted model P76149: TM-score 1.00, RMSD 0.30 Å
- 8QMR chain C against the predicted model P76149: TM-score 1.00, RMSD 0.33 Å
- 8QMT chain B against the predicted model P76149: TM-score 1.00, RMSD 0.33 Å
- 8QMT chain C against the predicted model P76149: TM-score 1.00, RMSD 0.33 Å
- 8QMR chain D against the predicted model P76149: TM-score 1.00, RMSD 0.35 Å
- 8QMR chain B against the predicted model P76149: TM-score 1.00, RMSD 0.36 Å
- 8QMR chain A against the predicted model P76149: TM-score 1.00, RMSD 0.43 Å
- 8QMT chain D against the predicted model P76149: TM-score 1.00, RMSD 0.44 Å
Elsewhere
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