UniProt P69741
Hydrogenase-2 small chain (P69741)
Hydrogenase-2 small chain (UniProt P69741), EC 1.12.99.6: 11 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P69741
- Protein
- Hydrogenase-2 small chain
- EC
- 1.12.99.6
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 14 · 2 records with a druggable one
Structures
12 records of P69741 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6EHQ | E. COLI hydrogenase-2 (as isolated form). | x-ray diffraction | S, T | SF4, F3S | — |
| 6EHS | E. coli Hydrogenase-2 chemically reduced structure | x-ray diffraction | S, T | SF4, F3S, DTN | — |
| 6EHS | E. COLI hydrogenase-2 chemically reduced structure | x-ray diffraction | S, T | SF4, F3S, DTN | — |
| 6EN9 | E. coli Hydrogenase-2 (hydrogen reduced form) | x-ray diffraction | S, T | SF4, F3S, SO4 | 7 (best 0.83) |
| 6EN9 | E. COLI hydrogenase-2 (hydrogen reduced form) | x-ray diffraction | S, T | SF4, F3S, SO4 | — |
| 6G7M | Four-site variant (Y222C, C197S, C432S, C433S) of E. coli hydrogenase-2 | x-ray diffraction | S, T | SF4, F3S | 7 (best 0.81) |
| 6G7M | Four-site variant (Y222C, C197S, C432S, C433S) of E. COLI hydrogenase- 2 | x-ray diffraction | S, T | SF4, F3S | — |
| 6GAM | Structure of E14Q variant of E. COLI hydrogenase-2 (as-isolated enzyme) | x-ray diffraction | S, T | SF4, F3S | — |
| 6GAN | Structure of fully reduced hydrogenase (hyd-2) variant E14Q | x-ray diffraction | S, T | SF4, F3S | — |
| 6SZD | Hydrogenase-2 variant R479K - hydrogen reduced form | x-ray diffraction | SSS, TTT | SF4, F3S, SO4 | — |
| 7NEM | Hydrogenase-2 variant R479K - anaerobically oxidised form | x-ray diffraction | S, T | SF4, F3S, CL | — |
| P69741 | AlphaFold monomer V2.0 prediction for hydrogenase-2 small chain (P69741) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6EHQ chain S against the predicted model P69741: TM-score 1.00, RMSD 0.19 Å
- 6EHS chain S against the predicted model P69741: TM-score 1.00, RMSD 0.21 Å
- 6EHS chain S against the predicted model P69741: TM-score 1.00, RMSD 0.21 Å
- 6EHQ chain T against the predicted model P69741: TM-score 1.00, RMSD 0.21 Å
- 6SZD chain SSS against the predicted model P69741: TM-score 1.00, RMSD 0.22 Å
- 7NEM chain S against the predicted model P69741: TM-score 1.00, RMSD 0.22 Å
- 6EN9 chain T against the predicted model P69741: TM-score 1.00, RMSD 0.22 Å
- 6EN9 chain S against the predicted model P69741: TM-score 1.00, RMSD 0.22 Å
- 6EN9 chain S against the predicted model P69741: TM-score 1.00, RMSD 0.22 Å
- 6GAM chain S against the predicted model P69741: TM-score 1.00, RMSD 0.22 Å
Elsewhere
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