UniProt P69739
Hydrogenase-1 small chain (P69739)
Hydrogenase-1 small chain (UniProt P69739), EC 1.12.99.6: 23 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 48 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P69739
- Protein
- Hydrogenase-1 small chain
- EC
- 1.12.99.6
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 48 · 5 records with a druggable one
Structures
24 records of P69739 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3UQY | H2-reduced structure of E. COLI hydrogenase-1 | x-ray diffraction | S, T | — | — |
| 3USC | Crystal Structure of E. coli hydrogenase-1 in a ferricyanide-oxidized form | x-ray diffraction | S, T | — | — |
| 3USC | Crystal structure of E. COLI hydrogenase-1 in a ferricyanide-oxidized form | x-ray diffraction | S, T | — | — |
| 3USE | Crystal structure of E. COLI hydrogenase-1 in its as-isolated form | x-ray diffraction | S, T | — | — |
| 4GD3 | Structure of E. coli hydrogenase-1 in complex with cytochrome b | x-ray diffraction | S, T, Q, R | — | — |
| 4GD3 | Structure of E. COLI hydrogenase-1 in complex with cytochrome B | x-ray diffraction | S, T, Q, R | — | — |
| 4UE3 | The Mechanism of Hydrogen Activation by NiFe-hydrogenases and the Importance of the active site… | x-ray diffraction | SSS, TTT | — | — |
| 5A4F | The mechanism of hydrogen activation by nife-hydrogenases. | x-ray diffraction | S, T | — | — |
| 5A4I | The mechanism of Hydrogen activation by NiFE-hydrogenases | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | 8 (best 0.81) |
| 5A4I | The mechanism of hydrogen activation by nife-hydrogenases | x-ray diffraction | S, T | — | — |
| 5A4M | Mechanism of hydrogen activation by nife-hydrogenases | x-ray diffraction | S, T | — | — |
| 5ADU | The Mechanism of Hydrogen Activation by NiFe-hydrogenases | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | 9 (best 0.80) |
| 5ADU | The mechanism of hydrogen activation by nife-hydrogenases | x-ray diffraction | S, T | — | — |
| 6FPI | Structure of fully reduced Hydrogenase (Hyd-1) variant E28Q | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | — |
| 6FPI | Structure of fully reduced hydrogenase (hyd-1) variant E28Q | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | — |
| 6FPW | Structure of fully reduced Hydrogenase (Hyd-1) | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | — |
| 6FPW | Structure of fully reduced hydrogenase (hyd-1) | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | — |
| 6G7R | Structure of fully reduced variant E28Q of E. coli hydrogenase-1 at pH 8 | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | 7 (best 0.80) |
| 6G7R | Structure of fully reduced variant E28Q of E. COLI hydrogenase-1 at pH 8 | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4 | — |
| 6G94 | Structure of E. coli hydrogenase-1 C19G variant in complex with cytochrome b | x-ray diffraction | S, T, Q, R | SF4, F3S, ER2 | 16 (best 0.86) |
| 6G94 | Structure of E. COLI hydrogenase-1 C19G variant in complex with cytochrome B | x-ray diffraction | S, T, Q, R | SF4, F3S, ER2 | — |
| 6GAL | Structure of fully reduced Hydrogenase (Hyd-1) variant E28Q collected at pH 10 | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4, LI | 8 (best 0.80) |
| 6GAL | Structure of fully reduced hydrogenase (hyd-1) variant E28Q collected at pH 10 | x-ray diffraction | S, T | SF4, F3S, SF3, CL, SO4, LI | — |
| P69739 | AlphaFold monomer V2.0 prediction for hydrogenase-1 small chain (P69739) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6G7R chain S against the predicted model P69739: TM-score 1.00, RMSD 0.22 Å
- 6G7R chain S against the predicted model P69739: TM-score 1.00, RMSD 0.22 Å
- 4UE3 chain SSS against the predicted model P69739: TM-score 1.00, RMSD 0.23 Å
- 3UQY chain S against the predicted model P69739: TM-score 1.00, RMSD 0.23 Å
- 6FPW chain S against the predicted model P69739: TM-score 1.00, RMSD 0.23 Å
- 6FPW chain S against the predicted model P69739: TM-score 1.00, RMSD 0.23 Å
- 5A4I chain S against the predicted model P69739: TM-score 1.00, RMSD 0.24 Å
- 5A4I chain S against the predicted model P69739: TM-score 1.00, RMSD 0.24 Å
- 5A4M chain T against the predicted model P69739: TM-score 1.00, RMSD 0.24 Å
- 5A4F chain S against the predicted model P69739: TM-score 1.00, RMSD 0.24 Å
Elsewhere
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