UniProt P68032
Actin, alpha cardiac muscle 1 (P68032)
Actin, alpha cardiac muscle 1 (UniProt P68032), EC 3.6.4.-: 4 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P68032
- Protein
- Actin, alpha cardiac muscle 1
- EC
- 3.6.4.-
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 23 · 4 records with a druggable one
Structures
5 records of P68032 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8GSW | Crystal structure of human cardiac alpha actin A108G mutant (AMPPNP state) in complex with fragmin… | x-ray diffraction | A | ANP, MG, PO4, CA | 5 (best 0.75) |
| 8GT2 | Crystal structure of human cardiac alpha actin P109A mutant (AMPPNP state) in complex with fragmin… | x-ray diffraction | A | ANP, MG, PO4, CA | 5 (best 0.75) |
| 8GT4 | Crystal structure of human cardiac alpha actin Q137A mutant (AMPPNP state) in complex with fragmin… | x-ray diffraction | A | ANP, MG, PO4, CA | 5 (best 0.77) |
| 9B3Q | The structure of the human cardiac F-actin mutant A331P | electron microscopy | A, D, E | MG, ADP | 8 (best 0.80) |
| P68032 | AlphaFold monomer V2.0 prediction for actin, alpha cardiac muscle 1 (P68032) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8GT2 chain A against the predicted model P68032: TM-score 0.98, RMSD 1.10 Å
- 8GT4 chain A against the predicted model P68032: TM-score 0.98, RMSD 1.16 Å
- 8GSW chain A against the predicted model P68032: TM-score 0.98, RMSD 1.17 Å
- 9B3Q chain A against the predicted model P68032: TM-score 0.96, RMSD 1.52 Å
- 9B3Q chain D against the predicted model P68032: TM-score 0.96, RMSD 1.56 Å
- 9B3Q chain E against the predicted model P68032: TM-score 0.96, RMSD 1.57 Å
Elsewhere
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