UniProt P63165
Small ubiquitin-related modifier 1 (P63165)
Small ubiquitin-related modifier 1 (UniProt P63165), EC 2.3.2.26: 103 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P63165
- Protein
- Small ubiquitin-related modifier 1
- EC
- 2.3.2.26
- Experimental structures
- 103
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 23 · 4 records with a druggable one
Structures
104 records of P63165 in the MolNFT archive: 103 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A5R | Structure determination of the small ubiquitin-related modifier sumo-1, NMR, 10 structures | solution nmr | A | — | — |
| 1A5R | Structure determination of the small ubiquitin-related modifier sumo- 1, NMR, 10 structures | solution nmr | A | — | — |
| 1TGZ | Structure of human Senp2 in complex with SUMO-1 | x-ray diffraction | B | — | — |
| 1TGZ | Structure of human SENP2 in complex with sumo-1 | x-ray diffraction | B | — | — |
| 1WYW | Crystal Structure of SUMO1-conjugated thymine DNA glycosylase | x-ray diffraction | B | — | — |
| 1WYW | Crystal structure of SUMO1-conjugated thymine DNA glycosylase | x-ray diffraction | B | — | — |
| 1Y8R | Sumo E1 activating enzyme SAE1-SAE2-SUMO1-mg-ATP complex | x-ray diffraction | C, F | — | — |
| 1Y8R | Sumo E1 activating enzyme SAE1-SAE2-SUMO1-mg-ATP complex | x-ray diffraction | C, F | — | — |
| 1Z5S | Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2 | x-ray diffraction | B | — | — |
| 1Z5S | Crystal structure of a complex between UBC9, sumo-1, RANGAP1 and NUP358/RANBP2 | x-ray diffraction | B | — | — |
| 2ASQ | Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM) | solution nmr | A | — | — |
| 2ASQ | Solution structure of sumo-1 in complex with a sumo-binding motif (sbm) | solution nmr | A | — | — |
| 2BF8 | Crystal structure of SUMO modified ubiquitin conjugating enzyme E2- 25K | x-ray diffraction | B | — | — |
| 2BF8 | Crystal structure of sumo modified ubiquitin conjugating enzyme E2-25K | x-ray diffraction | B | — | — |
| 2G4D | Crystal structure of human SENP1 mutant (C603S) in complex with SUMO-1 | x-ray diffraction | B, D | — | — |
| 2G4D | Crystal structure of human SENP1 mutant (C603S) in complex with sumo-1 | x-ray diffraction | B, D | — | — |
| 2IO2 | Crystal structure of human Senp2 in complex with RanGAP1-SUMO-1 | x-ray diffraction | B | — | — |
| 2IO2 | Crystal structure of human SENP2 in complex with RANGAP1-sumo-1 | x-ray diffraction | B | — | — |
| 2IY0 | SENP1 (mutant) SUMO1 RanGAP | x-ray diffraction | B | — | — |
| 2IY0 | SENP1 (mutant) SUMO1 rangap | x-ray diffraction | B | — | — |
| 2IY1 | SENP1 (mutant) full length SUMO1 | x-ray diffraction | B, D | — | — |
| 2IY1 | SENP1 (mutant) full length SUMO1 | x-ray diffraction | B, D | — | — |
| 2KQS | Phosphorylation of SUMO-interacting motif by CK2 enhances Daxx SUMO binding activity | solution nmr | A | — | — |
| 2KQS | Phosphorylation of sumo-interacting motif by CK2 enhances daxx sumo binding activity | solution nmr | A | — | — |
| 2LAS | Molecular Determinants of Paralogue-Specific SUMO-SIM Recognition | solution nmr | A | — | — |
| 2LAS | Molecular determinants of paralogue-specific sumo-sim recognition | solution nmr | A | — | — |
| 2MW5 | Backbone fold of Human Small Ubiquitin like Modifier protein-1 (SUMO-1) based on Prot3D-NMR… | solution nmr | A | — | — |
| 2MW5 | Backbone fold of human small ubiquitin like modifier protein-1 (sumo- 1) based on PROT3D-NMR… | solution nmr | A | — | — |
| 2N1A | Docked structure between SUMO1 and ZZ-domain from CBP | solution nmr | A | — | — |
| 2N1A | Docked structure between SUMO1 and zz-domain from cbp | solution nmr | A | — | — |
| 2N1V | Solution structure of human SUMO1 | solution nmr | A | — | — |
| 2N1V | Solution structure of human SUMO1 | solution nmr | A | — | — |
| 2PE6 | Non-covalent complex between human SUMO-1 and human Ubc9 | x-ray diffraction | B | — | — |
| 2PE6 | Non-covalent complex between human sumo-1 and human UBC9 | x-ray diffraction | B | — | — |
| 2UYZ | Non-covalent complex between Ubc9 and SUMO1 | x-ray diffraction | B | — | — |
| 2UYZ | Non-covalent complex between UBC9 and SUMO1 | x-ray diffraction | B | — | — |
| 2VRR | Structure of SUMO modified Ubc9 | x-ray diffraction | B | — | — |
| 2VRR | Structure of sumo modified UBC9 | x-ray diffraction | B | — | — |
| 3KYC | Human SUMO E1 complex with a SUMO1-AMP mimic | x-ray diffraction | D | — | — |
| 3KYC | Human sumo E1 complex with a SUMO1-AMP mimic | x-ray diffraction | D | — | — |
| 3KYD | Human SUMO E1~SUMO1-AMP tetrahedral intermediate mimic | x-ray diffraction | D | — | — |
| 3KYD | Human sumo E1~SUMO1-AMP tetrahedral intermediate mimic | x-ray diffraction | D | — | — |
| 3RZW | Crystal Structure of the Monobody ySMB-9 bound to human SUMO1 | x-ray diffraction | C, D | — | — |
| 3RZW | Crystal structure of the monobody ysmb-9 bound to human SUMO1 | x-ray diffraction | C, D | — | — |
| 3UIP | Complex between human RanGAP1-SUMO1, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II | x-ray diffraction | B | — | — |
| 3UIP | Complex between human RANGAP1-SUMO1, UBC9 and the IR1 domain from RANBP2 containing IR2 motif II | x-ray diffraction | B | — | — |
| 4WJN | Crystal structure of SUMO1 in complex with phosphorylated PML | x-ray diffraction | A | — | — |
| 4WJN | Crystal structure of SUMO1 in complex with phosphorylated pml | x-ray diffraction | A | — | — |
| 4WJO | Crystal Structure of SUMO1 in complex with PML | x-ray diffraction | A | — | — |
| 4WJO | Crystal structure of SUMO1 in complex with pml | x-ray diffraction | A | — | — |
| 4WJP | Crystal Structure of SUMO1 in complex with phosphorylated Daxx | x-ray diffraction | A, C | — | — |
| 4WJP | Crystal structure of SUMO1 in complex with phosphorylated daxx | x-ray diffraction | A, C | — | — |
| 4WJQ | Crystal Structure of SUMO1 in complex with Daxx | x-ray diffraction | A, C | — | — |
| 4WJQ | Crystal structure of SUMO1 in complex with daxx | x-ray diffraction | A, C | — | — |
| 5AEK | Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X | — | — |
| 5AEK | Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X | — | — |
| 5B7A | Solution structure of LYS37 acetylated human SUMO1 | solution nmr | A | — | — |
| 5B7A | Solution structure of LYS37 acetylated human SUMO1 | solution nmr | A | — | — |
| 5ELJ | Isoform-specific inhibition of SUMO-dependent protein-protein interactions | x-ray diffraction | B | — | — |
| 5ELJ | Isoform-specific inhibition of sumo-dependent protein-protein interactions | x-ray diffraction | B | — | — |
44 records more on the page itself.
Ligands
- ZN · Zinc ion · in 6 records
- VAY · {(1R,2R,3S,4R)-4-[(5-{4-[(1S)-1-(6-bromopyridin-2-yl)-1-hydroxyethyl]thiophene-2-carbonyl}pyrimidin-4-yl) amino]-2,3-dihydroxycyclopentyl}methyl sulfamate · in 2 records
- VB7 · {(1R,2S,4R)-4-[(5-{4-[(1R)-3,4-dihydro-1H-2-benzopyran-1-yl]thiophene-2-carbonyl}pyrimidin-4-yl)amino]-2-hydroxycyclopentyl}methyl sulfamate · in 2 records
- VBA · [(1R,2R,3S,4R)-4-{[5-(1-benzyl-1H-pyrazole-3-carbonyl) pyrimidin-4-yl]amino}-2,3-dihydroxycyclopentyl]methyl sulfamate · in 2 records
Experiment against prediction
- 6V7R chain C against the predicted model P63165: TM-score 0.98, RMSD 0.41 Å
- 6V7R chain C against the predicted model P63165: TM-score 0.98, RMSD 0.41 Å
- 6V7S chain C against the predicted model P63165: TM-score 0.98, RMSD 0.43 Å
- 6V7S chain C against the predicted model P63165: TM-score 0.98, RMSD 0.43 Å
- 3RZW chain C against the predicted model P63165: TM-score 0.98, RMSD 0.48 Å
- 3RZW chain C against the predicted model P63165: TM-score 0.98, RMSD 0.48 Å
- 6UYO chain A against the predicted model P63165: TM-score 0.98, RMSD 0.48 Å
- 6UYU chain C against the predicted model P63165: TM-score 0.98, RMSD 0.54 Å
- 6UYO chain C against the predicted model P63165: TM-score 0.97, RMSD 0.53 Å
- 6UYS chain C against the predicted model P63165: TM-score 0.97, RMSD 0.57 Å
Elsewhere
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