UniProt P63137
Gamma-aminobutyric acid receptor subunit beta-2 (P63137)
Gamma-aminobutyric acid receptor subunit beta-2 (UniProt P63137): 5 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 55 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P63137
- Protein
- Gamma-aminobutyric acid receptor subunit beta-2
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 55 · 4 records with a druggable one
Structures
6 records of P63137 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8FOI | Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA and… | electron microscopy | B, E | NAG, BMA, MAN, D12, POV, ABU | 14 (best 0.82) |
| 8G4N | Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA… | electron microscopy | B, E | NAG, MAN, Y4B, D12, POV, ABU | 14 (best 0.82) |
| 8G5F | Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | B, E | MAN, NAG, BMA, Y4B, ABU | 13 (best 0.83) |
| 8G5G | Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | B, E | NAG, MAN, Y4B, ABU | — |
| 8G5H | Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | B, E | NAG, MAN, BMA, ABU, Y4B | 14 (best 0.83) |
| P63137 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-2 (P63137) | predicted | A | — | — |
Ligands
- ABU · Gamma-amino-butanoic acid · in 5 records
- MAN · alpha-D-mannopyranose · in 5 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- Y4B · allopregnanolone · in 5 records
- BMA · beta-D-mannopyranose · in 3 records
- D12 · Dodecane · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
Experiment against prediction
- 8FOI chain E against the predicted model P63137: TM-score 0.99, RMSD 0.62 Å
- 8FOI chain B against the predicted model P63137: TM-score 0.99, RMSD 0.71 Å
- 8G4N chain E against the predicted model P63137: TM-score 0.99, RMSD 0.73 Å
- 8G5H chain E against the predicted model P63137: TM-score 0.99, RMSD 0.77 Å
- 8G4N chain B against the predicted model P63137: TM-score 0.99, RMSD 0.83 Å
- 8G5H chain B against the predicted model P63137: TM-score 0.98, RMSD 0.94 Å
- 8G5F chain E against the predicted model P63137: TM-score 0.98, RMSD 0.96 Å
- 8G5F chain B against the predicted model P63137: TM-score 0.97, RMSD 1.20 Å
- 8G5G chain B against the predicted model P63137: TM-score 0.94, RMSD 1.68 Å
- 8G5G chain E against the predicted model P63137: TM-score 0.94, RMSD 1.74 Å
Elsewhere
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