UniProt P63010
AP-2 complex subunit beta,F-BAR domain only protein 2 (P63010)
AP-2 complex subunit beta,F-BAR domain only protein 2 (UniProt P63010): 33 experimental structures and 1 predicted model on GenesisL1, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P63010
- Protein
- AP-2 complex subunit beta,F-BAR domain only protein 2
- Experimental structures
- 33
- Predicted models
- 1
- Pockets
- 9 · 1 record with a druggable one
Structures
34 records of P63010 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1E42 | Beta2-adaptin appendage domain, from clathrin adaptor AP2 | x-ray diffraction | A, B | — | — |
| 1E42 | BETA2-adaptin appendage domain, from clathrin adaptor AP2 | x-ray diffraction | A, B | — | — |
| 2G30 | beta appendage of AP2 complexed with ARH peptide | x-ray diffraction | A | — | — |
| 2G30 | Beta appendage of AP2 complexed with arh peptide | x-ray diffraction | A | — | — |
| 2IV8 | beta appendage in complex with b-arrestin peptide | x-ray diffraction | A | — | — |
| 2IV8 | Beta appendage in complex with B-arrestin peptide | x-ray diffraction | A | — | — |
| 2IV9 | B2-appendage from AP2 in complex with Eps15 peptide | x-ray diffraction | A, B | — | — |
| 2IV9 | B2-appendage from AP2 in complex with EPS15 peptide | x-ray diffraction | A, B | — | — |
| 2JKR | AP2 CLATHRIN ADAPTOR CORE with Dileucine peptide RM(phosphoS)QIKRLLSE | x-ray diffraction | B, E | — | — |
| 2JKR | AP2 clathrin adaptor core with dileucine peptide rm( PHOSPHOS)QIKRLLSE | x-ray diffraction | B, E | — | — |
| 2JKT | AP2 CLATHRIN ADAPTOR CORE with CD4 Dileucine peptide RM(phosphoS) EIKRLLSE Q to E mutant | x-ray diffraction | B, E | — | — |
| 2JKT | AP2 clathrin adaptor core with CD4 dileucine peptide rm( PHOSPHOS)EIKRLLSE Q to E mutant | x-ray diffraction | B, E | — | — |
| 2VGL | AP2 clathrin adaptor core | x-ray diffraction | B | — | — |
| 2VGL | AP2 clathrin adaptor core | x-ray diffraction | B | — | — |
| 2XA7 | AP2 clathrin adaptor core in active complex with cargo peptides | x-ray diffraction | B | — | — |
| 2XA7 | AP2 clathrin adaptor core in active complex with cargo peptides | x-ray diffraction | B | — | — |
| 4UQI | AP2 controls clathrin polymerization with a membrane-activated switch | x-ray diffraction | B | — | — |
| 4UQI | AP2 controls clathrin polymerization with a membrane-activated switch | x-ray diffraction | B | — | — |
| 5M5R | Clathrin heavy chain N-terminal domain bound to BETA2 adaptin clathrin box motif | x-ray diffraction | C, D | — | — |
| 6QH5 | AP2 clathrin adaptor MU2T156-phosphorylated core in closed conformation | x-ray diffraction | B | — | — |
| 6QH6 | AP2 clathrin adaptor core with two cargo peptides in open+ conformation | x-ray diffraction | B | — | — |
| 6QH7 | AP2 clathrin adaptor MU2T156-phosphorylated core with two cargo peptides in open+ conformation | x-ray diffraction | B | — | — |
| 6URI | HIV-1 nef in complex with the CD4 cytoplasmic domain and the AP2 clathrin adaptor complex | x-ray diffraction | B | — | — |
| 6YAE | AP2 core in physiological buffer | electron microscopy | B | — | — |
| 6YAF | AP2 on a membrane containing tyrosine-based cargo peptide | electron microscopy | B | — | — |
| 6YAF | AP2 on a membrane containing tyrosine-based cargo peptide | electron microscopy | B | — | — |
| 6YAH | AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo… | electron microscopy | B | — | — |
| 6YAH | AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo… | electron microscopy | B | — | — |
| 6YAI | Clathrin with bound beta2 appendage of AP2 | electron microscopy | F | — | — |
| 6YAI | Clathrin with bound BETA2 appendage of AP2 | electron microscopy | F | — | — |
| 7OHO | Crystal structure of AP2 FCHO2 chimera | x-ray diffraction | BBB | — | 9 (best 0.85) |
| 7OM8 | BETA2 appendage domain of AP2 bound to terminal domains beneath the hub of the 28 triskelia mini… | electron microscopy | B | — | — |
| 7Z5C | Chimera of AP2 with FCHO2 linker domain as a fusion on CMU2 subunit | electron microscopy | B | — | — |
| P63010 | AlphaFold monomer V2.0 prediction for ap-2 complex subunit beta (P63010) | predicted | A | — | — |
Experiment against prediction
- 2IV9 chain B against the predicted model P63010: TM-score 0.99, RMSD 0.55 Å
- 2IV9 chain B against the predicted model P63010: TM-score 0.99, RMSD 0.55 Å
- 2G30 chain A against the predicted model P63010: TM-score 0.99, RMSD 0.61 Å
- 2G30 chain A against the predicted model P63010: TM-score 0.99, RMSD 0.61 Å
- 1E42 chain B against the predicted model P63010: TM-score 0.99, RMSD 0.64 Å
- 1E42 chain B against the predicted model P63010: TM-score 0.99, RMSD 0.64 Å
- 1E42 chain A against the predicted model P63010: TM-score 0.99, RMSD 0.64 Å
- 1E42 chain A against the predicted model P63010: TM-score 0.99, RMSD 0.64 Å
- 6YAI chain F against the predicted model P63010: TM-score 0.99, RMSD 0.64 Å
- 6YAI chain F against the predicted model P63010: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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