UniProt P62938
Peptidyl-prolyl cis-trans isomerase A (P62938)
Peptidyl-prolyl cis-trans isomerase A (UniProt P62938), EC 5.2.1.8: 3 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P62938
- Protein
- Peptidyl-prolyl cis-trans isomerase A
- EC
- 5.2.1.8
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 7 · 2 records with a druggable one
Structures
4 records of P62938 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5HSV | X-Ray structure of a CypA-Alisporivir complex at 1.5 angstrom resolution | x-ray diffraction | A, B, C, D | CL | 2 (best 0.67) |
| 5HSV | X-ray structure of a cypa-alisporivir complex at 1.5 ångström resolution | x-ray diffraction | A, B, C, D | — | — |
| 9BGH | Crystal structure of KRAS G12D in a transition state mimetic complex with CYPA and RMC-7977 | x-ray diffraction | B, D | ZNI | 5 (best 0.81) |
| P62938 | AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase a (P62938) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 1 record
- ZNI · (1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide · in 1 record
Experiment against prediction
- 5HSV chain B against the predicted model P62938: TM-score 1.00, RMSD 0.29 Å
- 5HSV chain B against the predicted model P62938: TM-score 1.00, RMSD 0.29 Å
- 5HSV chain A against the predicted model P62938: TM-score 1.00, RMSD 0.36 Å
- 5HSV chain A against the predicted model P62938: TM-score 1.00, RMSD 0.36 Å
- 9BGH chain B against the predicted model P62938: TM-score 0.99, RMSD 0.34 Å
- 9BGH chain D against the predicted model P62938: TM-score 0.99, RMSD 0.37 Å
- 5HSV chain D against the predicted model P62938: TM-score 0.99, RMSD 0.44 Å
- 5HSV chain C against the predicted model P62938: TM-score 0.99, RMSD 0.45 Å
Elsewhere
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