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UniProt P61619

Protein transport protein Sec61 subunit alpha isoform 1 (P61619)

Protein transport protein Sec61 subunit alpha isoform 1 (UniProt P61619): 6 experimental structures on GenesisL1, 2 ligands bound, 32 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
P61619
Protein
Protein transport protein Sec61 subunit alpha isoform 1
Experimental structures
6
Predicted models
0
Ligands
2
Pockets
32 · 4 records with a druggable one

Structures

6 records of P61619 in the MolNFT archive: 6 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
8DNWCryo-EM structure of the human Sec61 complex in a partially-open apo state (Class 2)electron microscopyA—7 (best 0.70)
8DNYCryo-EM structure of the human Sec61 complex inhibited by decatransinelectron microscopyA——
8DNZCryo-EM structure of the human Sec61 complex inhibited by apratoxin Felectron microscopyA—10 (best 0.69)
8DO1Cryo-EM structure of the human Sec61 complex inhibited by ipomoeassin Felectron microscopyASXF9 (best 0.66)
8DO3Cryo-EM structure of the human Sec61 complex inhibited by eeyarestatin Ielectron microscopyASWR6 (best 0.75)
P61619AlphaFold monomer V2.0 prediction for protein transport protein SEC61 subunit alpha isoform 1…———

Ligands

  • SWR · N'-(4-chlorophenyl)-N-[(4R)-3-(4-chlorophenyl)-5,5-dimethyl-1-(2-{(2E)-2-[(2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]hydrazinyl}-2-oxoethyl)-2-oxoimidazolidin-4-yl]-N-hydroxyurea · in 1 record
  • SXF · [(1~{S},3~{R},4~{S},5~{R},6~{R},8~{R},10~{S},23~{R},24~{R},25~{R},26~{R})-5-acetyloxy-6-methyl-4,26-bis(oxidanyl)-17,20-bis(oxidanylidene)-10-pentyl-24-[(~{E})-3-phenylprop-2-enoyl]oxy-2,7,9,21,27-pentaoxatricyclo[21.3.1.0^{3,8}]heptacosan-25-yl] (~{E})-2-methylbut-2-enoate · in 1 record

Elsewhere

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