UniProt P61201
COP9 signalosome complex subunit 2 (P61201)
COP9 signalosome complex subunit 2 (UniProt P61201): 13 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P61201
- Protein
- COP9 signalosome complex subunit 2
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 11 · 2 records with a druggable one
Structures
14 records of P61201 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4D10 | Crystal structure of the COP9 signalosome | x-ray diffraction | B, J | — | — |
| 4D10 | Crystal structure of the COP9 signalosome | x-ray diffraction | B, J | — | — |
| 4D18 | Crystal structure of the COP9 signalosome | x-ray diffraction | B, J | — | — |
| 4D18 | Crystal structure of the COP9 signalosome | x-ray diffraction | B, J | — | — |
| 4WSN | Crystal structure of the COP9 signalosome, a P1 crystal form | x-ray diffraction | B, J, R, Z, h, p | — | — |
| 6A73 | Complex structure of CSN2 with IP6 | x-ray diffraction | A, B | IHP, SO4 | — |
| 6R6H | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | B | — | 5 (best 0.81) |
| 6R6H | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | B | — | — |
| 6R7F | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | B | — | — |
| 6R7H | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | B | — | — |
| 6R7I | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | B | — | 6 (best 0.86) |
| 6R7I | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | B | — | — |
| 6R7N | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | B | — | — |
| P61201 | AlphaFold monomer V2.0 prediction for COP9 signalosome complex subunit 2 (P61201) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4D10 chain B against the predicted model P61201: TM-score 0.90, RMSD 1.72 Å
- 4D10 chain B against the predicted model P61201: TM-score 0.90, RMSD 1.72 Å
- 4WSN chain R against the predicted model P61201: TM-score 0.90, RMSD 1.73 Å
- 4WSN chain J against the predicted model P61201: TM-score 0.90, RMSD 1.74 Å
- 4WSN chain B against the predicted model P61201: TM-score 0.89, RMSD 1.78 Å
- 4D10 chain J against the predicted model P61201: TM-score 0.89, RMSD 1.82 Å
- 4D10 chain J against the predicted model P61201: TM-score 0.89, RMSD 1.82 Å
- 4WSN chain Z against the predicted model P61201: TM-score 0.88, RMSD 1.95 Å
- 4WSN chain p against the predicted model P61201: TM-score 0.88, RMSD 2.12 Å
- 4WSN chain h against the predicted model P61201: TM-score 0.87, RMSD 2.13 Å
Elsewhere
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