UniProt P61073
C-X-C chemokine receptor type 4 (P61073)
C-X-C chemokine receptor type 4 (UniProt P61073): 24 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P61073
- Protein
- C-X-C chemokine receptor type 4
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 31 · 4 records with a druggable one
Structures
25 records of P61073 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2K03 | Structure of SDF1 in complex with the CXCR4 N-terminus containing a sulfotyrosine at postition 21 | solution nmr | B, D | — | — |
| 2K03 | Structure of SDF1 in complex with the CXCR4 N-terminus containing a sulfotyrosine at postition 21 | solution nmr | B, D | — | — |
| 2K04 | Structure of SDF1 in complex with the CXCR4 N-terminus containing no sulfotyrosines | solution nmr | B, D | — | — |
| 2K04 | Structure of SDF1 in complex with the CXCR4 N-terminus containing no sulfotyrosines | solution nmr | B, D | — | — |
| 2K05 | Structure of SDF1 in complex with the CXCR4 N-terminus containing sulfotyrosines at postitions 7… | solution nmr | B, D | — | — |
| 2K05 | Structure of SDF1 in complex with the CXCR4 N-terminus containing sulfotyrosines at postitions 7… | solution nmr | B, D | — | — |
| 2N55 | Structure of constitutively monomeric CXCL12 in complex with the CXCR4 N-terminus | solution nmr | B | — | — |
| 2N55 | Structure of constitutively monomeric CXCL12 in complex with the CXCR4 N-terminus | solution nmr | B | — | — |
| 3ODU | The 2.5 A structure of the CXCR4 chemokine receptor in complex with small molecule antagonist IT1t | x-ray diffraction | A, B | — | — |
| 3ODU | The 2.5 a structure of the CXCR4 chemokine receptor in complex with small molecule antagonist IT1T | x-ray diffraction | A, B | — | — |
| 3OE0 | Crystal structure of the CXCR4 chemokine receptor in complex with a cyclic peptide antagonist CVX15 | x-ray diffraction | A | — | — |
| 3OE0 | Crystal structure of the CXCR4 chemokine receptor in complex with a cyclic peptide antagonist CVX15 | x-ray diffraction | A | — | — |
| 3OE6 | Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t… | x-ray diffraction | A | — | — |
| 3OE6 | Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1T… | x-ray diffraction | A | — | — |
| 3OE8 | Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1t… | x-ray diffraction | A, B, C | — | — |
| 3OE8 | Crystal structure of the CXCR4 chemokine receptor in complex with a small molecule antagonist IT1T… | x-ray diffraction | A, B, C | — | — |
| 3OE9 | Crystal structure of the chemokine CXCR4 receptor in complex with a small molecule antagonist IT1t… | x-ray diffraction | A, B | — | — |
| 3OE9 | Crystal structure of the chemokine CXCR4 receptor in complex with a small molecule antagonist IT1T… | x-ray diffraction | A, B | — | — |
| 4RWS | Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target) | x-ray diffraction | A | — | — |
| 4RWS | Crystal structure of CXCR4 and viral chemokine antagonist vmip-II complex (psi community target) | x-ray diffraction | A | — | — |
| 8GP3 | Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C-X-C… | electron microscopy | V, U | — | 3 (best 0.82) |
| 8K3Z | Cryo-EM structure of CXCR4 in complex with CXCL12 | electron microscopy | A | — | 5 (best 0.81) |
| 8U4R | Structure of REGN7663-Fab bound CXCR4 | electron microscopy | R | CLR | 3 (best 0.86) |
| 8U4T | Structure of tetrameric CXCR4 in complex with REGN7663 Fab | electron microscopy | R, I, Q, AA | CLR, D21 | 20 (best 0.87) |
| P61073 | AlphaFold monomer V2.0 prediction for C-X-C chemokine receptor type 4 (P61073) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8U4R chain R against the predicted model P61073: TM-score 0.96, RMSD 1.28 Å
- 8U4T chain AA against the predicted model P61073: TM-score 0.96, RMSD 1.34 Å
- 8U4T chain I against the predicted model P61073: TM-score 0.96, RMSD 1.34 Å
- 8U4T chain Q against the predicted model P61073: TM-score 0.96, RMSD 1.34 Å
- 8U4T chain R against the predicted model P61073: TM-score 0.96, RMSD 1.34 Å
- 8K3Z chain A against the predicted model P61073: TM-score 0.92, RMSD 2.07 Å
- 3ODU chain A against the predicted model P61073: TM-score 0.59, RMSD 1.34 Å
- 3ODU chain A against the predicted model P61073: TM-score 0.59, RMSD 1.34 Å
- 3ODU chain B against the predicted model P61073: TM-score 0.60, RMSD 1.62 Å
- 3ODU chain B against the predicted model P61073: TM-score 0.60, RMSD 1.62 Å
Elsewhere
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