UniProt P54760
Ephrin type-B receptor 4 (P54760)
Ephrin type-B receptor 4 (UniProt P54760), EC 2.7.10.1: 45 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P54760
- Protein
- Ephrin type-B receptor 4
- EC
- 2.7.10.1
- Experimental structures
- 45
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 7 · 4 records with a druggable one
Structures
46 records of P54760 in the MolNFT archive: 45 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BBA | Crystal Structure and Thermodynamic Characterization of the EphB4 Receptor in Complex with an… | x-ray diffraction | A | — | — |
| 2BBA | Crystal structure and thermodynamic characterization of the EPHB4 receptor in complex with an… | x-ray diffraction | A | — | — |
| 2E7H | Solution structure of the second fn3 domain from human Ephrin type-B receptor 4 | solution nmr | A | — | — |
| 2E7H | Solution structure of the second FN3 domain from human ephrin type-B receptor 4 | solution nmr | A | — | — |
| 2HLE | Structural and biophysical characterization of the EPHB4-EPHRINB2 protein protein interaction and… | x-ray diffraction | A | — | — |
| 2HLE | Structural and biophysical characterization of the EPHB4-EPHRINB2 protein protein interaction and… | x-ray diffraction | A | — | — |
| 2QKQ | Structure of the SAM Domain of Human Ephrin Type-B Receptor 4 | x-ray diffraction | A, B | — | — |
| 2QKQ | Structure of the SAM domain of human ephrin type-B receptor 4 | x-ray diffraction | A, B | — | — |
| 2VWU | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWU | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWV | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWV | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWW | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWW | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWX | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWX | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWY | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWY | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWZ | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VWZ | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VX0 | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VX0 | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VX1 | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2VX1 | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2X9F | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2X9F | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2XVD | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2XVD | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 2YN8 | ephB4 kinase domain inhibitor complex | x-ray diffraction | A, B | — | — |
| 2YN8 | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A, B | — | — |
| 3ZEW | Crystal structure of EphB4 in complex with staurosporine | x-ray diffraction | A, B | — | — |
| 3ZEW | Crystal structure of EPHB4 in complex with staurosporine | x-ray diffraction | A, B | — | — |
| 4AW5 | Complex of the EphB4 kinase domain with an oxindole inhibitor | x-ray diffraction | A | — | — |
| 4AW5 | Complex of the EPHB4 kinase domain with an oxindole inhibitor | x-ray diffraction | A | — | — |
| 4BB4 | ephB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 4BB4 | EPHB4 kinase domain inhibitor complex | x-ray diffraction | A | — | — |
| 6FNI | Crystal structure of ephrin B4 (EPHB4) receptor protein kinase with nvp-BHG712 | x-ray diffraction | A | DXH | — |
| 6FNJ | Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with an isomer of NVP-BHG712 | x-ray diffraction | A, B | DWT | 4 (best 0.67) |
| 6FNJ | Crystal structure of ephrin B4 (EPHB4) receptor protein kinase with an isomer of nvp-BHG712 | x-ray diffraction | A, B | DWT | — |
| 6FNK | Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with a pyrazolo[3,4-d]pyrimidine… | x-ray diffraction | A | DXK | 1 (best 0.66) |
| 6FNK | Crystal structure of ephrin B4 (EPHB4) receptor protein kinase with a PYRAZOLO[3,4-D]PYRIMIDINE… | x-ray diffraction | A | DXK | — |
| 6FNL | Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase | x-ray diffraction | A | — | 1 (best 0.61) |
| 6FNL | Crystal structure of ephrin B4 (EPHB4) receptor protein kinase | x-ray diffraction | A | — | — |
| 6FNM | Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with Dasatinib | x-ray diffraction | A | 1N1 | 1 (best 0.67) |
| 6FNM | Crystal structure of ephrin B4 (EPHB4) receptor protein kinase with dasatinib | x-ray diffraction | A | 1N1 | — |
| P54760 | AlphaFold monomer V2.0 prediction for ephrin type-B receptor 4 (P54760) | predicted | A | — | — |
Ligands
- 1N1 · N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide · in 2 records
- DWT · 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl) phenyl]benzamide · in 2 records
- DXK · 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine · in 2 records
- DXH · 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl) phenyl]benzamide · in 1 record
Experiment against prediction
- 2VWW chain A against the predicted model P54760: TM-score 0.99, RMSD 0.55 Å
- 2VWW chain A against the predicted model P54760: TM-score 0.99, RMSD 0.55 Å
- 2VWU chain A against the predicted model P54760: TM-score 0.99, RMSD 0.57 Å
- 2VWU chain A against the predicted model P54760: TM-score 0.99, RMSD 0.57 Å
- 2VWV chain A against the predicted model P54760: TM-score 0.99, RMSD 0.58 Å
- 2VWV chain A against the predicted model P54760: TM-score 0.99, RMSD 0.58 Å
- 6FNL chain A against the predicted model P54760: TM-score 0.99, RMSD 0.70 Å
- 6FNL chain A against the predicted model P54760: TM-score 0.99, RMSD 0.70 Å
- 4AW5 chain A against the predicted model P54760: TM-score 0.99, RMSD 0.70 Å
- 4AW5 chain A against the predicted model P54760: TM-score 0.99, RMSD 0.70 Å
Elsewhere
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