UniProt P53927
Ribosome biogenesis protein 15 (P53927)
Ribosome biogenesis protein 15 (UniProt P53927): 37 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P53927
- Protein
- Ribosome biogenesis protein 15
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 25 · 15 records with a druggable one
Structures
38 records of P53927 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3JCT | Cryo-em structure of eukaryotic pre-60S ribosomal subunits | electron microscopy | o | — | — |
| 5T9P | Structural analysis reveals the flexible C-terminus of Nop15 undergoes rearrangement to recognize a… | x-ray diffraction | B, C, A, D | SO4, CL | 4 (best 0.70) |
| 5T9P | Structural analysis reveals the flexible C-terminus of NOP15 undergoes rearrangement to recognize a… | x-ray diffraction | B, C, A, D | SO4, CL | — |
| 5Z3G | Cryo-EM structure of a nucleolar pre-60S ribosome (Rpf1-TAP) | electron microscopy | E | — | 2 (best 0.86) |
| 5Z3G | Cryo-EM structure of a nucleolar pre-60S ribosome (RPF1-tap) | electron microscopy | E | — | — |
| 6C0F | Yeast nucleolar pre-60S ribosomal subunit (state 2) | electron microscopy | o | — | — |
| 6C0F | Yeast nucleolar pre-60S ribosomal subunit (state 2) | electron microscopy | o | — | — |
| 6CB1 | Yeast nucleolar pre-60S ribosomal subunit (state 3) | electron microscopy | o | — | 1 (best 0.81) |
| 6CB1 | Yeast nucleolar pre-60S ribosomal subunit (state 3) | electron microscopy | o | — | — |
| 6ELZ | State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | electron microscopy | o | — | — |
| 6EM1 | State C (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | electron microscopy | o | — | 1 (best 0.87) |
| 6EM3 | State A architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar… | electron microscopy | o | — | — |
| 6EM3 | State a architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | o | — | — |
| 6EM4 | State B architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar… | electron microscopy | o | — | 2 (best 0.72) |
| 6EM4 | State B architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | o | — | — |
| 6EM5 | State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar… | electron microscopy | o | — | 1 (best 0.69) |
| 6EM5 | State D architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | o | — | — |
| 6M62 | Cryo-Em structure of eukaryotic pre-60S ribosome subunit from Saccharomyces cerevisiae rpf2 delta… | electron microscopy | o | — | — |
| 6YLX | pre-60S State NE1 (TAP-Flag-Nop53) | electron microscopy | o | — | 1 (best 0.87) |
| 6YLY | pre-60S State NE2 (TAP-Flag-Nop53) | electron microscopy | o | — | — |
| 7BTB | Cryo-EM structure of pre-60S ribosome from Saccharomyces cerevisiae rpl4delta63-87 strain at 3.22… | electron microscopy | o | — | — |
| 7NAC | State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model | electron microscopy | o | — | — |
| 7OHP | Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL25 expression shut… | electron microscopy | o | — | 2 (best 0.81) |
| 7OHQ | Nog1-TAP associated immature ribosomal particle population C from S. cerevisiae | electron microscopy | o | — | — |
| 7OHR | Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae | electron microscopy | o | — | — |
| 7OHS | Nog1-TAP associated immature ribosomal particle population F from S. cerevisiae | electron microscopy | o | — | — |
| 7OHV | Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL2 expression shut… | electron microscopy | o | — | 1 (best 0.85) |
| 7OHX | Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL34 expression shut… | electron microscopy | o | — | 2 (best 0.81) |
| 7R6Q | State E2 nucleolar 60S ribosome biogenesis intermediate - Foot region model | electron microscopy | o | — | 3 (best 0.86) |
| 7R7A | State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model | electron microscopy | o | — | 2 (best 0.86) |
| 7U0H | State NE1 nucleolar 60S ribosome biogenesis intermediate - Overall model | electron microscopy | o | — | — |
| 7UOO | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state | electron microscopy | o | — | — |
| 7UQB | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1-D52A… | electron microscopy | o | — | — |
| 7UQZ | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1 D52A strain | electron microscopy | o | — | — |
| 8E5T | Yeast co-transcriptional Noc1-Noc2 RNP assembly checkpoint intermediate | electron microscopy | o | — | 1 (best 0.75) |
| 8V83 | 60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map) | electron microscopy | o | — | 1 (best 0.85) |
| 8V84 | 60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map) | electron microscopy | o | — | 1 (best 0.84) |
| P53927 | AlphaFold monomer V2.0 prediction for ribosome biogenesis protein 15 (P53927) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7OHX chain o against the predicted model P53927: TM-score 0.94, RMSD 0.99 Å
- 7NAC chain o against the predicted model P53927: TM-score 0.94, RMSD 1.03 Å
- 8V84 chain o against the predicted model P53927: TM-score 0.94, RMSD 1.12 Å
- 7UQB chain o against the predicted model P53927: TM-score 0.94, RMSD 1.13 Å
- 8V83 chain o against the predicted model P53927: TM-score 0.94, RMSD 1.15 Å
- 7UQZ chain o against the predicted model P53927: TM-score 0.94, RMSD 1.13 Å
- 7R6Q chain o against the predicted model P53927: TM-score 0.94, RMSD 1.14 Å
- 7R7A chain o against the predicted model P53927: TM-score 0.94, RMSD 1.07 Å
- 3JCT chain o against the predicted model P53927: TM-score 0.94, RMSD 1.07 Å
- 7UOO chain o against the predicted model P53927: TM-score 0.94, RMSD 1.17 Å
Elsewhere
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