UniProt P53145
Large subunit GTPase 1 (P53145)
Large subunit GTPase 1 (UniProt P53145), EC 3.6.1.-: 7 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P53145
- Protein
- Large subunit GTPase 1
- EC
- 3.6.1.-
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 12 · 1 record with a druggable one
Structures
8 records of P53145 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5T62 | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome… | electron microscopy | W | GNP, MG | — |
| 6N8N | Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit | electron microscopy | W | — | — |
| 6N8O | Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit | electron microscopy | W | — | — |
| 6QIK | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | o | — | — |
| 6QTZ | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | o | — | — |
| 6RI5 | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | o | — | — |
| 6S05 | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | o | — | — |
| P53145 | AlphaFold monomer V2.0 prediction for large subunit GTPase 1 (P53145) | predicted | A | — | 12 (best 0.79) |
Ligands
Experiment against prediction
- 5T62 chain W against the predicted model P53145: TM-score 0.96, RMSD 1.36 Å
- 6QIK chain o against the predicted model P53145: TM-score 0.92, RMSD 2.04 Å
- 6N8N chain W against the predicted model P53145: TM-score 0.92, RMSD 2.43 Å
- 6N8O chain W against the predicted model P53145: TM-score 0.92, RMSD 2.12 Å
- 6RI5 chain o against the predicted model P53145: TM-score 0.92, RMSD 2.05 Å
- 6QTZ chain o against the predicted model P53145: TM-score 0.92, RMSD 2.13 Å
- 6S05 chain o against the predicted model P53145: TM-score 0.91, RMSD 2.10 Å
Elsewhere
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