UniProt P52699
Beta-lactamase IMP-1 (P52699)
Beta-lactamase IMP-1 (UniProt P52699), EC 3.5.2.6: 41 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 43 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P52699
- Protein
- Beta-lactamase IMP-1
- EC
- 3.5.2.6
- Experimental structures
- 41
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 43 · 6 records with a druggable one
Structures
42 records of P52699 in the MolNFT archive: 41 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DD6 | Imp-1 metallo beta-lactamase from pseudomonas aeruginosa in complex with a mercaptocarboxylate… | x-ray diffraction | A, B | — | — |
| 1DD6 | Imp-1 metallo beta-lactamase from pseudomonas aeruginosa in complex with a mercaptocarboxylate… | x-ray diffraction | A, B | — | — |
| 1JJE | Imp-1 metallo beta-lactamase from pseudomonas aeruginosa in complex with a biaryl succinic acid… | x-ray diffraction | A, B | — | — |
| 1JJE | Imp-1 metallo beta-lactamase from pseudomonas aeruginosa in complex with a biaryl succinic acid… | x-ray diffraction | A, B | — | — |
| 1JJT | Imp-1 metallo beta-lactamase from pseudomonas aeruginosa in complex with a biaryl succinic acid… | x-ray diffraction | A, B | — | — |
| 1JJT | Imp-1 metallo beta-lactamase from pseudomonas aeruginosa in complex with a biaryl succinic acid… | x-ray diffraction | A, B | — | — |
| 1VGN | Structure-based design of the irreversible inhibitors to metallo--lactamase (IMP-1) | x-ray diffraction | A, B | — | — |
| 1VGN | Structure-based design of the irreversible inhibitors to metallo--lactamase (imp-1) | x-ray diffraction | A, B | — | — |
| 1WUO | Crystal structure of metallo-beta-lactamase IMP-1 mutant (D81A) | x-ray diffraction | A, B, C, D | — | — |
| 1WUO | Crystal structure of metallo-beta-lactamase imp-1 mutant (D81A) | x-ray diffraction | A, B, C, D | — | — |
| 1WUP | Crystal structure of metallo-beta-lactamase IMP-1 mutant (D81E) | x-ray diffraction | A, B, C, D | — | — |
| 1WUP | Crystal structure of metallo-beta-lactamase imp-1 mutant (D81E) | x-ray diffraction | A, B, C, D | — | — |
| 2DOO | The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe | x-ray diffraction | A, B | — | — |
| 2DOO | The structure of imp-1 complexed with the detecting reagent (DANSYLC4SH) by a fluorescent probe | x-ray diffraction | A, B | — | — |
| 4C1F | Crystal structure of the metallo-beta-lactamase IMP-1 with L-captopril | x-ray diffraction | A, B | — | — |
| 4C1F | Crystal structure of the metallo-beta-lactamase imp-1 with L-captopril | x-ray diffraction | A, B | — | — |
| 4C1G | Crystal structure of the metallo-beta-lactamase IMP-1 with D-captopril | x-ray diffraction | A, B | — | — |
| 4C1G | Crystal structure of the metallo-beta-lactamase imp-1 with D-captopril | x-ray diffraction | A, B | — | — |
| 5EV6 | Crystal structure of the native, di-zinc metallo-beta-lactamase IMP-1 | x-ray diffraction | A, B, C, D | ZN | 9 (best 0.78) |
| 5EV6 | Crystal structure of the native, di-zinc metallo-beta-lactamase imp-1 | x-ray diffraction | A, B, C, D | — | — |
| 5EV8 | Crystal structure of the metallo-beta-lactamase IMP-1 in complex with the bisthiazolidine inhibitor… | x-ray diffraction | A, B, C, D | ZN, 3R9, NA, CL | 7 (best 0.77) |
| 5EV8 | Crystal structure of the metallo-beta-lactamase imp-1 in complex with the bisthiazolidine inhibitor… | x-ray diffraction | A, B, C, D | — | — |
| 5EWA | Crystal structure of the metallo-beta-lactamase IMP-1 in complex with the bisthiazolidine inhibitor… | x-ray diffraction | A, B, C, D | ZN, 9BZ | — |
| 5EWA | Crystal structure of the metallo-beta-lactamase imp-1 in complex with the bisthiazolidine inhibitor… | x-ray diffraction | A, B, C, D | — | — |
| 5HH4 | Crystal structure of metallo-beta-lactamase IMP-1 in complex with a phosphonate-based inhibitor | x-ray diffraction | A, B, C, D | ZN, 60M, CL | — |
| 5HH4 | Crystal structure of metallo-beta-lactamase imp-1 in complex with a phosphonate-based inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 5Y5B | Crystal Structure Of IMP-1 Metallo-beta-lactamase | x-ray diffraction | A | ZN, SO4 | — |
| 5Y5B | Crystal structure of imp-1 metallo-beta-lactamase | x-ray diffraction | A | ZN, SO4 | — |
| 6JED | Crystal structure of IMP-1 metallo-beta-lactamase in a complex with MCR | x-ray diffraction | A | ZN, MCR | 1 (best 0.50) |
| 6JED | Crystal structure of imp-1 metallo-beta-lactamase in a complex with mcr | x-ray diffraction | A | ZN, MCR | — |
| 6JKA | Crystal structure of metallo-beta-lactamse, IMP-1, in complex with a thiazole-bearing inhibitor | x-ray diffraction | A, B, C, D | ZN, BS0, BQU | — |
| 6JKA | Crystal structure of metallo-beta-lactamse, imp-1, in complex with a thiazole-bearing inhibitor | x-ray diffraction | A, B, C, D | ZN, BS0, BQU | — |
| 6LBL | Crystal structure of IMP-1 metallo-beta-lactamase in complex with NO9 inhibitor | x-ray diffraction | A | ZN, NA, NO9 | 1 (best 0.48) |
| 6LBL | Crystal structure of imp-1 metallo-beta-lactamase in complex with NO9 inhibitor | x-ray diffraction | A | ZN, NA, NO9 | — |
| 6ZYR | Structure of IMP-1 with 2-Mercaptomethyl-thiazolidine L-anti-1b | x-ray diffraction | A, B, C, D | ZN, QT2, NA | 8 (best 0.77) |
| 6ZYR | Structure of imp-1 with 2-mercaptomethyl-thiazolidine L-anti-1B | x-ray diffraction | A, B, C, D | ZN, QT2, NA | — |
| 6ZYS | Structure of IMP-1 with 2-Mercaptomethyl-thiazolidine D-syn-1b | x-ray diffraction | A, B, C, D | ZN, QST | 10 (best 0.79) |
| 6ZYS | Structure of imp-1 with 2-mercaptomethyl-thiazolidine D-syn-1B | x-ray diffraction | A, B, C, D | ZN, QST | — |
| 7DTM | Crystal structure of metallo-beta-lactamase IMP-1 in complex with citrate. | x-ray diffraction | A, B, C, D | ZN | 7 (best 0.79) |
| 7DTM | Crystal structure of metallo-beta-lactamase imp-1 in complex with citrate. | x-ray diffraction | A, B, C, D | ZN | — |
| 7DTN | Crystal structure of metallo-beta-lactamase imp-1 mutant (D120E) in complex with citrate. | x-ray diffraction | A, B, C, D | ZN, AE3 | — |
| P52699 | AlphaFold monomer V2.0 prediction for metallo-beta-lactamase type 2 (P52699) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 19 records
- NA · Sodium ion · in 5 records
- BQU · 3-[2-azanyl-5-[2-(phenoxymethyl)-1,3-thiazol-4-yl]phenyl]propanoic acid · in 2 records
- BS0 · 6-[2-(phenoxymethyl)-1,3-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one · in 2 records
- CL · Chloride ion · in 2 records
- MCR · Sulfanylacetic acid · in 2 records
- NO9 · 2,5-dimethyl-4-sulfamoyl-furan-3-carboxylic acid · in 2 records
- QST · (2~{S},4~{S})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid · in 2 records
- QT2 · (2~{S},4~{R})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- 3R9 · (3S,5S,7aR)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid · in 1 record
- 60M · 6-(phosphonomethyl)pyridine-2-carboxylic acid · in 1 record
- 9BZ · (3~{R},5~{R},7~{a}~{S})-2,2-dimethyl-5-(sulfanylmethyl)-3,5,7,7~{a}-tetrahydro-[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid · in 1 record
- AE3 · 2-(2-ethoxyethoxy)ethanol · in 1 record
Experiment against prediction
- 6ZYS chain A against the predicted model P52699: TM-score 1.00, RMSD 0.30 Å
- 6ZYS chain A against the predicted model P52699: TM-score 1.00, RMSD 0.30 Å
- 6ZYR chain A against the predicted model P52699: TM-score 1.00, RMSD 0.31 Å
- 6ZYR chain A against the predicted model P52699: TM-score 1.00, RMSD 0.31 Å
- 5EV8 chain A against the predicted model P52699: TM-score 1.00, RMSD 0.32 Å
- 5HH4 chain A against the predicted model P52699: TM-score 1.00, RMSD 0.32 Å
- 5HH4 chain A against the predicted model P52699: TM-score 1.00, RMSD 0.32 Å
- 5EWA chain A against the predicted model P52699: TM-score 1.00, RMSD 0.34 Å
- 5EWA chain A against the predicted model P52699: TM-score 1.00, RMSD 0.34 Å
- 5EV6 chain A against the predicted model P52699: TM-score 1.00, RMSD 0.36 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.