UniProt P51787
Potassium voltage-gated channel subfamily KQT member 1 (P51787)
Potassium voltage-gated channel subfamily KQT member 1 (UniProt P51787): 20 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 125 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P51787
- Protein
- Potassium voltage-gated channel subfamily KQT member 1
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 125 · 6 records with a druggable one
Structures
21 records of P51787 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3BJ4 | The KCNQ1 (Kv7.1) C-terminus, a multi-tiered scaffold for subunit assembly and protein interaction | x-ray diffraction | A, B | — | — |
| 3BJ4 | The KCNQ1 (KV7.1) C-terminus, a multi-tiered scaffold for subunit assembly and protein interaction | x-ray diffraction | A, B | — | — |
| 3HFC | A trimeric form of the Kv7.1 A domain Tail, L602M/L606M mutant Semet | x-ray diffraction | A, B, C | — | — |
| 3HFC | A trimeric form of the KV7.1 a domain tail, L602M/L606M mutant semet | x-ray diffraction | A, B, C | — | — |
| 3HFE | A trimeric form of the Kv7.1 A domain Tail | x-ray diffraction | A, B, C | — | — |
| 3HFE | A trimeric form of the KV7.1 a domain tail | x-ray diffraction | A, B, C | — | — |
| 4UMO | Crystal Structure of the Kv7.1 proximal C-terminal Domain in Complex with Calmodulin | x-ray diffraction | A, B | — | — |
| 4UMO | Crystal structure of the KV7.1 proximal C-terminal domain in complex with calmodulin | x-ray diffraction | A, B | — | — |
| 4V0C | Crystal Structure of the Kv7.1 proximal C-terminal Domain in Complex with Calmodulin | x-ray diffraction | A, B | — | — |
| 4V0C | Crystal structure of the KV7.1 proximal C-terminal domain in complex with calmodulin | x-ray diffraction | A, B | — | — |
| 6MIE | Solution NMR structure of the KCNQ1 voltage-sensing domain | solution nmr | A | — | — |
| 6UZZ | structure of human KCNQ1-CaM complex | electron microscopy | A, C, E, G | — | 20 (best 0.84) |
| 6UZZ | Structure of human KCNQ1-cam complex | electron microscopy | A, C, E, G | — | — |
| 6V00 | Structure of human KCNQ1-KCNE3-cam complex | electron microscopy | A, D, G, J | — | — |
| 6V01 | Structure of human KCNQ1-KCNE3-cam complex with PIP2 | electron microscopy | A, J, D, G | PT5 | — |
| 7XNI | human KCNQ1-CaM in apo state | electron microscopy | A, B, D, G | — | 20 (best 0.84) |
| 7XNK | human KCNQ1-CaM in complex with ML277 | electron microscopy | A, C, E, G | K, I0S | 20 (best 0.79) |
| 7XNL | human KCNQ1-CaM-ML277-PIP2 complex in state A | electron microscopy | A, C, E, G | K, I0S, PIO | 20 (best 0.80) |
| 7XNN | human KCNQ1-CaM-ML277-PIP2 complex in state B | electron microscopy | B, C, E, G | K, I0S, PIO | 20 (best 0.80) |
| 8SIK | KCNQ1 with voltage sensor in the up conformation | electron microscopy | A, G, C, E | — | 20 (best 0.84) |
| P51787 | AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily kqt member 1… | predicted | A | — | 5 (best 0.49) |
Ligands
- I0S · (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide · in 3 records
- K · Potassium ion · in 3 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 2 records
- PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · in 1 record
Experiment against prediction
- 6UZZ chain A against the predicted model P51787: TM-score 0.98, RMSD 1.05 Å
- 6UZZ chain A against the predicted model P51787: TM-score 0.98, RMSD 1.05 Å
- 8SIK chain A against the predicted model P51787: TM-score 0.96, RMSD 1.31 Å
- 7XNK chain A against the predicted model P51787: TM-score 0.96, RMSD 1.46 Å
- 6V00 chain A against the predicted model P51787: TM-score 0.96, RMSD 1.38 Å
- 7XNL chain A against the predicted model P51787: TM-score 0.96, RMSD 1.50 Å
- 7XNI chain A against the predicted model P51787: TM-score 0.92, RMSD 2.21 Å
- 3BJ4 chain B against the predicted model P51787: TM-score 0.87, RMSD 1.60 Å
- 3BJ4 chain B against the predicted model P51787: TM-score 0.87, RMSD 1.60 Å
- 3BJ4 chain A against the predicted model P51787: TM-score 0.87, RMSD 1.49 Å
Elsewhere
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