UniProt P50172
P50172
P50172 (UniProt P50172): 12 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P50172
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 4
Structures
13 records of P50172 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Y5M | The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target… | x-ray diffraction | A, B | — | — |
| 1Y5M | The crystal structure of murine 11B-hydroxysteroid dehydrogenase: an important therapeutic target… | x-ray diffraction | A, B | — | — |
| 1Y5R | The crystal structure of murine 11b-hydroxysteroid dehydrogenase complexed with corticosterone | x-ray diffraction | A, B | — | — |
| 1Y5R | The crystal structure of murine 11B-hydroxysteroid dehydrogenase complexed with corticosterone | x-ray diffraction | A, B | — | — |
| 3GMD | Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3GMD | Structure-based design of 7-azaindole-pyrrolidines as inhibitors of… | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4K26 | 4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment… | x-ray diffraction | A, B | — | — |
| 4K26 | 4,4-dioxo-5,6-dihydro-[1,4,3]OXATHIAZINES, a novel class of 11 -HSD1 inhibitors for the treatment… | x-ray diffraction | A, B | — | — |
| 4NMH | 11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one | x-ray diffraction | A, B, C, D | — | — |
| 4NMH | 11-beta-HSD1 in complex with a 3,3-di-methyl-azetidin-2-one | x-ray diffraction | A, B, C, D | — | — |
| 5PGZ | Crystal structure of murine 11BETA- hydroxysteroiddehydrogenase complexed with… | x-ray diffraction | A, B | NAP, 8KG, SO4 | — |
| 5QIJ | Crystal structure of murine 11B- hydroxysteroiddehydrogenase complexed with 2-(3-(1-(4… | x-ray diffraction | A, B | NAP, HJG, SO4 | — |
| P50172 | AlphaFold monomer V2.0 prediction for corticosteroid 11-beta- dehydrogenase isozyme 1 (P50172) | predicted | A | — | — |
Ligands
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 2 records
- SO4 · Sulfate ion · in 2 records
- 8KG · 2-[(5R,7S)-6-hydroxy-2-phenyladamantan-2-yl]-1-(3-hydroxyazetidin-1-yl)ethan-1-one · in 1 record
- HJG · 2-{3-[1-(4-chlorophenyl)cyclopropyl][1,2,4]triazolo[4, 3-a]pyridin-8-yl}propan-2-ol · in 1 record
Experiment against prediction
- 5PGZ chain A against the predicted model P50172: TM-score 1.00, RMSD 0.32 Å
- 1Y5M chain A against the predicted model P50172: TM-score 1.00, RMSD 0.33 Å
- 1Y5M chain A against the predicted model P50172: TM-score 1.00, RMSD 0.33 Å
- 5QIJ chain B against the predicted model P50172: TM-score 1.00, RMSD 0.35 Å
- 1Y5M chain B against the predicted model P50172: TM-score 1.00, RMSD 0.36 Å
- 1Y5M chain B against the predicted model P50172: TM-score 1.00, RMSD 0.36 Å
- 5QIJ chain A against the predicted model P50172: TM-score 1.00, RMSD 0.36 Å
- 3GMD chain F against the predicted model P50172: TM-score 1.00, RMSD 0.36 Å
- 3GMD chain F against the predicted model P50172: TM-score 1.00, RMSD 0.36 Å
- 3GMD chain B against the predicted model P50172: TM-score 1.00, RMSD 0.37 Å
Elsewhere
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