UniProt P49840
Glycogen synthase kinase-3 alpha (P49840)
Glycogen synthase kinase-3 alpha (UniProt P49840), EC 2.7.11.1, 2.7.11.26: 1 experimental structure and 1 predicted model on GenesisL1, 1 ligand bound, 2 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P49840
- Protein
- Glycogen synthase kinase-3 alpha
- EC
- 2.7.11.1, 2.7.11.26
- Experimental structures
- 1
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 2 · 1 record with a druggable one
Structures
2 records of P49840 in the MolNFT archive: 1 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7SXG | BIO-8546 bound GSK3alpha-axin complex | x-ray diffraction | A | D1E | 2 (best 0.64) |
| P49840 | AlphaFold monomer V2.0 prediction for glycogen synthase kinase-3 alpha (P49840) | predicted | A | — | — |
Ligands
- D1E · (4S,5R,8R)-4-ethyl-8-fluoro-4-[3-(3-fluoro-5-methoxypyridin-4-yl)phenyl]-7,7-dimethyl-4,5,6,7,8,9-hexahydro-2H-pyrazolo[3,4-b]quinolin-5-ol · in 1 record
Experiment against prediction
- 7SXG chain A against the predicted model P49840: TM-score 0.98, RMSD 0.94 Å
Elsewhere
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