UniProt P49682
Soluble cytochrome b562,C-X-C chemokine receptor type 3,Kappa-type opioid receptor (P49682)
Soluble cytochrome b562,C-X-C chemokine receptor type 3,Kappa-type opioid receptor (UniProt P49682), EC 1.13.12.13: 2 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 10 pockets. Binding sites…
- UniProt
- P49682
- Protein
- Soluble cytochrome b562,C-X-C chemokine receptor type 3,Kappa-type opioid…
- EC
- 1.13.12.13
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 10 · 2 records with a druggable one
Structures
3 records of P49682 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8HNK | CXCR3-DNGi complex activated by CXCL11 | electron microscopy | R | CLR | 5 (best 0.72) |
| 8K2W | Structure of CXCR3 complexed with antagonist AMG487 | electron microscopy | R | CLR, PCW, LPC, FI6 | 5 (best 0.71) |
| P49682 | AlphaFold monomer V2.0 prediction for C-X-C chemokine receptor type 3 (P49682) | predicted | A | — | — |
Ligands
- CLR · Cholesterol · in 2 records
- FI6 · N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxidanylidene-pyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethyloxy)phenyl]ethanamide · in 1 record
- LPC · [1-myristoyl-glycerol-3-yl]phosphonylcholine · in 1 record
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 1 record
Experiment against prediction
- 8HNK chain R against the predicted model P49682: TM-score 0.93, RMSD 1.99 Å
- 8K2W chain R against the predicted model P49682: TM-score 0.91, RMSD 1.83 Å
- 8K2W chain R against the predicted model P41145: TM-score 0.87, RMSD 2.46 Å
- 8HNK chain R against the predicted model P0ABE7: TM-score 0.25, RMSD 4.40 Å
- 8K2W chain R against the predicted model P0ABE7: TM-score 0.26, RMSD 4.21 Å
- 8HNK chain R against the predicted model Q9GV45: TM-score 0.23, RMSD 5.44 Å
Elsewhere
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