UniProt P49427
Ubiquitin-conjugating enzyme E2 R1 (P49427)
Ubiquitin-conjugating enzyme E2 R1 (UniProt P49427), EC 2.3.2.23, 2.3.2.24: 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 4 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P49427
- Protein
- Ubiquitin-conjugating enzyme E2 R1
- EC
- 2.3.2.23, 2.3.2.24
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 4 · 1 record with a druggable one
Structures
9 records of P49427 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2OB4 | Human Ubiquitin-Conjugating Enzyme CDC34 | x-ray diffraction | A | — | — |
| 2OB4 | Human ubiquitin-conjugating enzyme CDC34 | x-ray diffraction | A | — | — |
| 3RZ3 | Human Cdc34 E2 in complex with CC0651 inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 3RZ3 | Human CDC34 E2 in complex with CC0651 inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4MDK | Cdc34-ubiquitin-CC0651 complex | x-ray diffraction | A, B, C, D | — | — |
| 4MDK | CDC34-ubiquitin-CC0651 complex | x-ray diffraction | A, B, C, D | — | — |
| 7M2K | CDC34A-ubiquitin-2AB inhibitor complex | x-ray diffraction | A, C, E, G | GZM | — |
| 8RX0 | (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub | electron microscopy | G | — | 3 (best 0.72) |
| P49427 | AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 R1 (P49427) | predicted | A | — | 1 (best 0.41) |
Ligands
- GZM · 4-[(3',5'-dichloro[1,1'-biphenyl]-4-yl)methyl]-N-ethyl-1-(methoxyacetyl)piperidine-4-carboxamide · in 1 record
Experiment against prediction
- 8RX0 chain G against the predicted model P49427: TM-score 0.99, RMSD 0.32 Å
- 7M2K chain G against the predicted model P49427: TM-score 0.97, RMSD 0.89 Å
- 7M2K chain A against the predicted model P49427: TM-score 0.96, RMSD 0.97 Å
- 4MDK chain D against the predicted model P49427: TM-score 0.96, RMSD 0.94 Å
- 4MDK chain D against the predicted model P49427: TM-score 0.96, RMSD 0.94 Å
- 7M2K chain C against the predicted model P49427: TM-score 0.96, RMSD 1.02 Å
- 7M2K chain E against the predicted model P49427: TM-score 0.96, RMSD 0.98 Å
- 4MDK chain A against the predicted model P49427: TM-score 0.96, RMSD 1.04 Å
- 4MDK chain A against the predicted model P49427: TM-score 0.96, RMSD 1.04 Å
- 4MDK chain B against the predicted model P49427: TM-score 0.95, RMSD 1.09 Å
Elsewhere
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