UniProt P49257
Protein ERGIC-53 (P49257)
Protein ERGIC-53 (UniProt P49257): 29 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 215 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49257
- Protein
- Protein ERGIC-53
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 215 · 17 records with a druggable one
Structures
30 records of P49257 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3A4U | Crystal structure of MCFD2 in complex with carbohydrate recognition domain of ERGIC-53 | x-ray diffraction | A | CA | 3 (best 0.49) |
| 3A4U | Crystal structure of MCFD2 in complex with carbohydrate recognition domain of ergic-53 | x-ray diffraction | A | CA | 3 (best 0.49) |
| 3LCP | Crystal structure of the carbohydrate recognition domain of LMAN1 in complex with MCFD2 | x-ray diffraction | A, B | CA | 8 (best 0.60) |
| 3LCP | Crystal structure of the carbohydrate recognition domain of LMAN1 in complex with MCFD2 | x-ray diffraction | A, B | CA | 8 (best 0.60) |
| 3WHT | Crystal structure of ERGIC-53/MCFD2, Calcium-free form | x-ray diffraction | A | CL | 2 (best 0.50) |
| 3WHT | Crystal structure of ergic-53/MCFD2, calcium-free form | x-ray diffraction | A | — | — |
| 3WHU | Crystal structure of ERGIC-53/MCFD2, Calcium/Man2-bound form | x-ray diffraction | A | MAN, CA | 2 (best 0.58) |
| 3WHU | Crystal structure of ergic-53/MCFD2, CALCIUM/MAN2-bound form | x-ray diffraction | A | — | — |
| 3WNX | Crystal structure of ERGIC-53/MCFD2, Calcium/Man3-bound form | x-ray diffraction | A | MAN, CA | 2 (best 0.56) |
| 3WNX | Crystal structure of ergic-53/MCFD2, CALCIUM/MAN3-bound form | x-ray diffraction | A | — | — |
| 4GKX | Crystal structure of a carbohydrate-binding domain | x-ray diffraction | A, B, C, D, E, F | MAN, CA | 9 (best 0.76) |
| 4GKX | Crystal structure of a carbohydrate-binding domain | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4GKY | Crystal structure of a carbohydrate-binding domain | x-ray diffraction | A | CA, MAN | 1 (best 0.27) |
| 4GKY | Crystal structure of a carbohydrate-binding domain | x-ray diffraction | A | — | — |
| 4YGB | Crystal structure of ERGIC-53/MCFD2, monoclinic calcium-free form | x-ray diffraction | A, C | — | 6 (best 0.57) |
| 4YGB | Crystal structure of ergic-53/MCFD2, monoclinic calcium-free form | x-ray diffraction | A, C | — | — |
| 4YGC | Crystal structure of ERGIC-53/MCFD2, monoclinic calcium-bound form 1 | x-ray diffraction | A, C, E, G | CA, CL | 14 (best 0.70) |
| 4YGC | Crystal structure of ergic-53/MCFD2, monoclinic calcium-bound form 1 | x-ray diffraction | A, C, E, G | — | — |
| 4YGD | Crystal structure of ERGIC-53/MCFD2, monoclinic calcium-bound form 2 | x-ray diffraction | A, C, E, G | CA, CL | 13 (best 0.66) |
| 4YGD | Crystal structure of ergic-53/MCFD2, monoclinic calcium-bound form 2 | x-ray diffraction | A, C, E, G | — | — |
| 4YGE | Crystal structure of ERGIC-53/MCFD2, trigonal calcium-bound form 2 | x-ray diffraction | A, C, E | CA, CL | 9 (best 0.66) |
| 4YGE | Crystal structure of ergic-53/MCFD2, trigonal calcium-bound form 2 | x-ray diffraction | A, C, E | — | — |
| 8JP4 | Cryo-EM structure of the head region of full-length ERGIC-53 with MCFD2 (form A) | electron microscopy | A, B, E, F | CA | 18 (best 0.77) |
| 8JP5 | Cryo-EM structures of the head region of full-length ERGIC-53 with MCFD2 (form B) | electron microscopy | A, B, E, F | CA | 19 (best 0.80) |
| 8JP6 | Cryo-EM structures of the head region of full-length ERGIC-53 with MCFD2 (Substate A) | electron microscopy | A, B, E, F | CA | 20 (best 0.74) |
| 8JP7 | Cryo-EM structure of the head region of full-length ERGIC-53 with MCFD2 (Substate B) | electron microscopy | A, B, E, F | CA | 18 (best 0.76) |
| 8JP8 | Cryo-EM structure of the head region of full-length ERGIC-53 with MCFD2 (Substate C) | electron microscopy | A, B, E, F | CA | 20 (best 0.77) |
| 8JP9 | Cryo-EM structure of the head region of full-length ERGIC-53 with MCFD2 (Substate D) | electron microscopy | A, B, E, F | CA | 20 (best 0.76) |
| 8JPG | Cryo-EM structure of full-length ERGIC-53 with MCFD2 | electron microscopy | A, B, E, F | CA | 17 (best 0.82) |
| P49257 | AlphaFold monomer V2.0 prediction for protein ergic-53 (P49257) | predicted | A | — | 3 (best 0.63) |
Ligands
Experiment against prediction
- 3LCP chain A against the predicted model P49257: TM-score 1.00, RMSD 0.28 Å
- 3LCP chain A against the predicted model P49257: TM-score 1.00, RMSD 0.28 Å
- 4YGC chain C against the predicted model P49257: TM-score 1.00, RMSD 0.28 Å
- 4YGC chain C against the predicted model P49257: TM-score 1.00, RMSD 0.28 Å
- 4GKY chain A against the predicted model P49257: TM-score 1.00, RMSD 0.30 Å
- 4GKY chain A against the predicted model P49257: TM-score 1.00, RMSD 0.30 Å
- 4YGC chain A against the predicted model P49257: TM-score 1.00, RMSD 0.31 Å
- 4YGC chain A against the predicted model P49257: TM-score 1.00, RMSD 0.31 Å
- 4YGE chain A against the predicted model P49257: TM-score 1.00, RMSD 0.31 Å
- 4YGE chain A against the predicted model P49257: TM-score 1.00, RMSD 0.31 Å
Elsewhere
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