UniProt P48547
Potassium voltage-gated channel subfamily C member 1 (P48547)
Potassium voltage-gated channel subfamily C member 1 (UniProt P48547): 8 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 122 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P48547
- Protein
- Potassium voltage-gated channel subfamily C member 1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 122 · 7 records with a druggable one
Structures
9 records of P48547 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7PQT | Apo human Kv3.1 cryo-EM structure | electron microscopy | A, B, C, D | K | 20 (best 0.83) |
| 7PQT | Apo human KV3.1 cryo-EM structure | electron microscopy | A, B, C, D | K | — |
| 7PQU | Ligand-bound human Kv3.1 cryo-EM structure (Lu AG00563) | electron microscopy | A, B, C, D | 805, K | 18 (best 0.83) |
| 7PQU | Ligand-bound human KV3.1 cryo-EM structure (lu AG00563) | electron microscopy | A, B, C, D | 805, K | — |
| 8F1C | Voltage-gated potassium channel Kv3.1 with novel positive modulator… | electron microscopy | A, B, C, D | ZN, X9T, POV, K | 20 (best 0.82) |
| 8F1D | Voltage-gated potassium channel Kv3.1 apo | electron microscopy | A, B, C, D | ZN, CLR, K | 20 (best 0.83) |
| 8QUC | Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT1 | electron microscopy | A, B, D, C | WY9, PCF, ZN, Y01, K | 20 (best 0.83) |
| 8QUD | Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT5 | electron microscopy | A, B, D, C | WY0, ZN, Y01, PCF, K | 20 (best 0.84) |
| P48547 | AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily C member 1 (P48547) | predicted | A | — | 4 (best 0.60) |
Ligands
- K · Potassium ion · in 8 records
- ZN · Zinc ion · in 4 records
- 805 · 1-(4-methylphenyl)sulfonyl-N-(1,3-oxazol-2-ylmethyl) pyrrole-3-carboxamide · in 2 records
- PCF · 1,2-diacyl-sn-glycero-3-phoshocholine · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- CLR · Cholesterol · in 1 record
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 1 record
- WY0 · (5R)-5-ethyl-3-(6-spiro[2H-1-benzofuran-3,1'-cyclopropane]-4-yloxypyridin-3-yl)imidazolidine-2,4-dione · in 1 record
- WY9 · (5R)-5-ethyl-3-[6-(3-methoxy-4-methyl-phenoxy)pyridin-3-yl]imidazolidine-2,4-dione · in 1 record
- X9T · (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one · in 1 record
Experiment against prediction
- 7PQT chain C against the predicted model P48547: TM-score 0.92, RMSD 1.98 Å
- 7PQT chain D against the predicted model P48547: TM-score 0.92, RMSD 1.99 Å
- 7PQT chain A against the predicted model P48547: TM-score 0.92, RMSD 1.99 Å
- 7PQT chain A against the predicted model P48547: TM-score 0.92, RMSD 1.99 Å
- 7PQT chain B against the predicted model P48547: TM-score 0.92, RMSD 2.00 Å
- 8F1D chain A against the predicted model P48547: TM-score 0.91, RMSD 2.40 Å
- 7PQU chain A against the predicted model P48547: TM-score 0.91, RMSD 2.20 Å
- 7PQU chain A against the predicted model P48547: TM-score 0.91, RMSD 2.20 Å
- 7PQU chain B against the predicted model P48547: TM-score 0.91, RMSD 2.20 Å
- 7PQU chain D against the predicted model P48547: TM-score 0.91, RMSD 2.20 Å
Elsewhere
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