UniProt P46595
Ubiquitin-conjugating enzyme E2 4 (P46595)
Ubiquitin-conjugating enzyme E2 4 (UniProt P46595), EC 2.3.2.23: 20 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 101 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P46595
- Protein
- Ubiquitin-conjugating enzyme E2 4
- EC
- 2.3.2.23
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 101 · 18 records with a druggable one
Structures
21 records of P46595 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4II2 | Crystal structure of Ubiquitin activating enzyme 1 (Uba1) in complex with the Ub E2 Ubc4… | x-ray diffraction | C | — | — |
| 4II2 | Crystal structure of ubiquitin activating enzyme 1 (UBA1) in complex with the ub E2 UBC4… | x-ray diffraction | C | — | — |
| 9B56 | Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 2 | electron microscopy | A | A1AIV | 5 (best 0.77) |
| 9B57 | Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 3 | electron microscopy | A | A1AIV | 4 (best 0.77) |
| 9B58 | Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 4 | electron microscopy | A | A1AIV | 3 (best 0.78) |
| 9B59 | Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 5 | electron microscopy | A | A1AIV | 3 (best 0.80) |
| 9B5A | Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 6 | electron microscopy | A | A1AIV | 3 (best 0.80) |
| 9B5B | Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 7 | electron microscopy | A | A1AIV | 2 (best 0.82) |
| 9B5D | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class… | electron microscopy | C | A1AIV | 8 (best 0.78) |
| 9B5F | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 1… | electron microscopy | C | A1AIV | 4 (best 0.79) |
| 9B5G | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 2… | electron microscopy | C | A1AIV | 5 (best 0.79) |
| 9B5I | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 4… | electron microscopy | C | A1AIV | 7 (best 0.79) |
| 9B5K | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class… | electron microscopy | C | A1AIV | 6 (best 0.73) |
| 9B5L | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class… | electron microscopy | C | A1AIV | 9 (best 0.78) |
| 9B5N | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class… | electron microscopy | C | A1AIV | 6 (best 0.74) |
| 9B5O | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class… | electron microscopy | C | A1AIV | 8 (best 0.75) |
| 9B5S | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 4… | electron microscopy | C | A1AIV | 7 (best 0.76) |
| 9B5U | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class… | electron microscopy | C | A1AIV | 7 (best 0.75) |
| 9B5W | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class… | electron microscopy | C | A1AIV | 6 (best 0.79) |
| 9B5X | Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class… | electron microscopy | C | A1AIV | 8 (best 0.76) |
| P46595 | AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 4 (P46595) | predicted | A | — | — |
Ligands
- A1AIV · 4-aminobutanenitrile · in 18 records
Experiment against prediction
- 9B5B chain A against the predicted model P46595: TM-score 0.98, RMSD 0.66 Å
- 4II2 chain C against the predicted model P46595: TM-score 0.97, RMSD 0.81 Å
- 4II2 chain C against the predicted model P46595: TM-score 0.97, RMSD 0.81 Å
- 9B59 chain A against the predicted model P46595: TM-score 0.98, RMSD 0.71 Å
- 9B57 chain A against the predicted model P46595: TM-score 0.97, RMSD 0.87 Å
- 9B56 chain A against the predicted model P46595: TM-score 0.97, RMSD 0.87 Å
- 9B5S chain C against the predicted model P46595: TM-score 0.97, RMSD 0.76 Å
- 9B5O chain C against the predicted model P46595: TM-score 0.97, RMSD 0.76 Å
- 9B5D chain C against the predicted model P46595: TM-score 0.97, RMSD 0.77 Å
- 9B5N chain C against the predicted model P46595: TM-score 0.97, RMSD 0.77 Å
Elsewhere
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