UniProt P46095
G-protein coupled receptor 6, Soluble cytochrome b562 chimera (P46095)
G-protein coupled receptor 6, Soluble cytochrome b562 chimera (UniProt P46095): 4 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 20 pockets. Binding sites, druggability and experiment against…
- UniProt
- P46095
- Protein
- G-protein coupled receptor 6, Soluble cytochrome b562 chimera
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 20 · 4 records with a druggable one
Structures
5 records of P46095 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8T1V | Crystal structure of orphan G protein-coupled receptor 6 with bound inverse agonist 3h | x-ray diffraction | A | XY8, NA | 6 (best 0.77) |
| 8T1W | Crystal structure of orphan G protein-coupled receptor 6 with bound CVN424 | x-ray diffraction | A | X7T | 6 (best 0.76) |
| 8TF5 | Crystal structure of orphan G protein-coupled receptor 6, pseudoapo form | x-ray diffraction | A | P15, OLA, CLR | 3 (best 0.78) |
| 8TYW | cryo-EM structure of GPR6-Gs-Nb35 complex | electron microscopy | A | — | 5 (best 0.79) |
| P46095 | AlphaFold monomer V2.0 prediction for G-protein coupled receptor 6 (P46095) | predicted | A | — | — |
Ligands
- CLR · Cholesterol · in 1 record
- NA · Sodium ion · in 1 record
- OLA · Oleic acid · in 1 record
- P15 · 2,5,8,11,14,17-hexaoxanonadecan-19-ol · in 1 record
- X7T · 1-{2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-{[(3R)-oxolan-3-yl]amino}-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl}ethan-1-one · in 1 record
- XY8 · 3-{4-[(2,4-difluorophenyl)methyl]piperazin-1-yl}-7-methyl-N-(propan-2-yl)pyrido[3,4-b]pyrazin-2-amine · in 1 record
Experiment against prediction
- 8TYW chain A against the predicted model P46095: TM-score 0.96, RMSD 1.42 Å
- 8TF5 chain A against the predicted model P0ABE7: TM-score 0.29, RMSD 2.33 Å
- 8TF5 chain A against the predicted model P46095: TM-score 0.74, RMSD 1.22 Å
- 8T1W chain A against the predicted model P0ABE7: TM-score 0.28, RMSD 2.50 Å
- 8T1V chain A against the predicted model P46095: TM-score 0.72, RMSD 2.35 Å
- 8T1W chain A against the predicted model P46095: TM-score 0.72, RMSD 2.28 Å
- 8T1V chain A against the predicted model P0ABE7: TM-score 0.27, RMSD 2.58 Å
Elsewhere
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