UniProt P45299
Penicillin-binding protein activator LpoA (P45299)
Penicillin-binding protein activator LpoA (UniProt P45299): 12 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P45299
- Protein
- Penicillin-binding protein activator LpoA
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 35 · 7 records with a druggable one
Structures
13 records of P45299 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3CKM | LpoA (YraM) C-domain from Haemophilus influenzae, a regulator of PBP1A | x-ray diffraction | A | SO4 | 2 (best 0.64) |
| 3CKM | Lpoa (yram) C-domain from haemophilus influenzae, a regulator of PBP1A | x-ray diffraction | A | — | — |
| 4P29 | Crystal structure of the LpoA N-terminal domain from Haemophilus influenzae | x-ray diffraction | A, B | SO4, CL | 3 (best 0.64) |
| 4P29 | Crystal structure of the lpoa N-terminal domain from haemophilus influenzae | x-ray diffraction | A, B | — | — |
| 5KCN | Crystal Structure of full-length LpoA from Haemophilus influenzae at 1.97 angstrom resolution | x-ray diffraction | A | CL | 6 (best 0.64) |
| 5KCN | Crystal structure of full-length lpoa from haemophilus influenzae at 1.97 ångström resolution | x-ray diffraction | A | CL | — |
| 5VAT | Haemophilus influenzae LpoA: Monoclinic form (Mon2) with 2 molecules per a.u. | x-ray diffraction | A, B | — | 10 (best 0.65) |
| 5VAT | Haemophilus influenzae lpoa: monoclinic form (MON2) with 2 molecules per A.U. | x-ray diffraction | A, B | — | — |
| 5VBG | Crystal Structure of full-length LpoA, Monoclinic form 1, from Haemophilus influenzae | x-ray diffraction | A | CL | 5 (best 0.59) |
| 5VBG | Crystal structure of full-length lpoa, monoclinic form 1, from haemophilus influenzae | x-ray diffraction | A | CL | — |
| 6DCJ | LpoA N-terminal domain from Haemophilus influenzae; monoclinic form at 1.35 A resolution | x-ray diffraction | A, B | CL | 5 (best 0.64) |
| 6DCJ | Lpoa N-terminal domain from haemophilus influenzae; monoclinic form at 1.35 a resolution | x-ray diffraction | A, B | CL | — |
| P45299 | AlphaFold monomer V2.0 prediction for penicillin-binding protein activator lpoa (P45299) | predicted | A | — | 4 (best 0.62) |
Ligands
Experiment against prediction
- 4P29 chain A against the predicted model P45299: TM-score 0.99, RMSD 0.51 Å
- 4P29 chain A against the predicted model P45299: TM-score 0.99, RMSD 0.51 Å
- 5VBG chain A against the predicted model P45299: TM-score 0.99, RMSD 0.87 Å
- 5VBG chain A against the predicted model P45299: TM-score 0.99, RMSD 0.87 Å
- 3CKM chain A against the predicted model P45299: TM-score 0.99, RMSD 0.75 Å
- 3CKM chain A against the predicted model P45299: TM-score 0.99, RMSD 0.75 Å
- 4P29 chain B against the predicted model P45299: TM-score 0.99, RMSD 0.67 Å
- 4P29 chain B against the predicted model P45299: TM-score 0.99, RMSD 0.67 Å
- 5KCN chain A against the predicted model P45299: TM-score 0.97, RMSD 1.45 Å
- 5KCN chain A against the predicted model P45299: TM-score 0.97, RMSD 1.45 Å
Elsewhere
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