UniProt P45208
5,10-methylenetetrahydrofolate reductase (P45208)
5,10-methylenetetrahydrofolate reductase (UniProt P45208), EC 1.5.1.20: 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 18 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P45208
- Protein
- 5,10-methylenetetrahydrofolate reductase
- EC
- 1.5.1.20
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 18 · 1 record with a druggable one
Structures
3 records of P45208 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5UME | Crystal Structure of 5,10-Methylenetetrahydrofolate Reductase MetF from Haemophilus influenzae | x-ray diffraction | A, B, C, D, E, F | FAD, SO4 | 18 (best 0.82) |
| 5UME | Crystal structure of 5,10-methylenetetrahydrofolate reductase metf from haemophilus influenzae | x-ray diffraction | A, B, C, D, E, F | FAD, SO4 | — |
| P45208 | AlphaFold monomer V2.0 prediction for 5,10-methylenetetrahydrofolate reductase (P45208) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5UME chain C against the predicted model P45208: TM-score 0.99, RMSD 0.62 Å
- 5UME chain C against the predicted model P45208: TM-score 0.99, RMSD 0.62 Å
- 5UME chain B against the predicted model P45208: TM-score 0.99, RMSD 0.58 Å
- 5UME chain B against the predicted model P45208: TM-score 0.99, RMSD 0.58 Å
- 5UME chain A against the predicted model P45208: TM-score 0.99, RMSD 0.63 Å
- 5UME chain A against the predicted model P45208: TM-score 0.99, RMSD 0.63 Å
- 5UME chain F against the predicted model P45208: TM-score 0.99, RMSD 0.68 Å
- 5UME chain F against the predicted model P45208: TM-score 0.99, RMSD 0.68 Å
- 5UME chain D against the predicted model P45208: TM-score 0.98, RMSD 0.89 Å
- 5UME chain D against the predicted model P45208: TM-score 0.98, RMSD 0.89 Å
Elsewhere
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