UniProt P43116
Prostaglandin E2 receptor EP2 subtype (P43116)
Prostaglandin E2 receptor EP2 subtype (UniProt P43116): 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P43116
- Protein
- Prostaglandin E2 receptor EP2 subtype
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 19 · 4 records with a druggable one
Structures
7 records of P43116 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7CX2 | Cryo-EM structure of the PGE2-bound EP2-Gs complex | electron microscopy | R | P2E | 5 (best 0.82) |
| 7CX2 | Cryo-EM structure of the PGE2-bound EP2-gs complex | electron microscopy | R | P2E | — |
| 7CX3 | Cryo-EM structure of the Taprenepag-bound EP2-Gs complex | electron microscopy | R | GNO | 4 (best 0.81) |
| 7CX3 | Cryo-EM structure of the taprenepag-bound EP2-gs complex | electron microscopy | R | GNO | — |
| 7CX4 | Cryo-EM structure of the Evatanepag-bound EP2-Gs complex | electron microscopy | R | GM9 | 5 (best 0.83) |
| 7CX4 | Cryo-EM structure of the evatanepag-bound EP2-gs complex | electron microscopy | R | GM9 | — |
| P43116 | AlphaFold monomer V2.0 prediction for prostaglandin E2 receptor EP2 subtype (P43116) | predicted | A | — | 5 (best 0.78) |
Ligands
- GM9 · 2-[3-[[(4-~{tert}-butylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid · in 2 records
- GNO · 2-[3-[[(4-pyrazol-1-ylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid · in 2 records
- P2E · (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid · in 2 records
Experiment against prediction
- 7CX2 chain R against the predicted model P43116: TM-score 0.91, RMSD 2.19 Å
- 7CX2 chain R against the predicted model P43116: TM-score 0.91, RMSD 2.19 Å
- 7CX3 chain R against the predicted model P43116: TM-score 0.91, RMSD 2.26 Å
- 7CX3 chain R against the predicted model P43116: TM-score 0.91, RMSD 2.26 Å
- 7CX4 chain R against the predicted model P43116: TM-score 0.90, RMSD 2.20 Å
- 7CX4 chain R against the predicted model P43116: TM-score 0.90, RMSD 2.20 Å
Elsewhere
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