UniProt P43115
Prostaglandin E2 receptor EP3 subtype (P43115)
Prostaglandin E2 receptor EP3 subtype (UniProt P43115), EC 3.2.1.17: 7 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P43115
- Protein
- Prostaglandin E2 receptor EP3 subtype
- EC
- 3.2.1.17
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 27 · 5 records with a druggable one
Structures
8 records of P43115 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6AK3 | Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2 | x-ray diffraction | B, A | P2E, POV | 9 (best 0.84) |
| 6AK3 | Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2 | x-ray diffraction | B, A | P2E, POV | — |
| 6M9T | Crystal structure of EP3 receptor bound to misoprostol-FA | x-ray diffraction | A | J9P, SO4, OLA | 4 (best 0.85) |
| 6M9T | Crystal structure of EP3 receptor bound to misoprostol-fa | x-ray diffraction | A | J9P, SO4, OLA | — |
| 7WU9 | Cryo-EM structure of the human EP3-Gi signaling complex | electron microscopy | R | — | 3 (best 0.82) |
| 7WU9 | The structure of the GPCR-G-protein complex | electron microscopy | R | — | — |
| 8GDC | Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein | electron microscopy | R | P2E | 7 (best 0.81) |
| P43115 | AlphaFold monomer V2.0 prediction for prostaglandin E2 receptor EP3 subtype (P43115) | predicted | A | — | 4 (best 0.80) |
Ligands
- P2E · (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid · in 3 records
- J9P · (11alpha,12alpha,13E,16S)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid · in 2 records
- OLA · Oleic acid · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 8GDC chain R against the predicted model P43115: TM-score 0.93, RMSD 1.79 Å
- 6AK3 chain B against the predicted model P43115: TM-score 0.93, RMSD 1.66 Å
- 6AK3 chain B against the predicted model P43115: TM-score 0.93, RMSD 1.66 Å
- 6AK3 chain A against the predicted model P43115: TM-score 0.92, RMSD 1.62 Å
- 6AK3 chain A against the predicted model P43115: TM-score 0.92, RMSD 1.62 Å
- 7WU9 chain R against the predicted model P43115: TM-score 0.92, RMSD 2.16 Å
- 7WU9 chain R against the predicted model P43115: TM-score 0.92, RMSD 2.16 Å
- 6M9T chain A against the predicted model P43115: TM-score 0.60, RMSD 2.79 Å
- 6M9T chain A against the predicted model P43115: TM-score 0.60, RMSD 2.79 Å
- 6AK3 chain B against the predicted model P0ABE7: TM-score 0.26, RMSD 4.27 Å
Elsewhere
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