UniProt P42166
Lamina-associated polypeptide 2, isoform alpha,Integrase chimera (P42166)
Lamina-associated polypeptide 2, isoform alpha,Integrase chimera (UniProt P42166), EC 2.7.7.-, 3.1.-.-: 11 experimental structures on GenesisL1, 4 ligands bound, 119 pockets. Binding sites, pockets, druggability and 3D structures…
- UniProt
- P42166
- Protein
- Lamina-associated polypeptide 2, isoform alpha,Integrase chimera
- EC
- 2.7.7.-, 3.1.-.-
- Experimental structures
- 11
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 119 · 6 records with a druggable one
Structures
11 records of P42166 in the MolNFT archive: 11 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GJJ | N-terminal constant region of the nuclear envelope protein LAP2 | solution nmr | A | — | — |
| 1GJJ | N-terminal constant region of the nuclear envelope protein LAP2 | solution nmr | A | — | — |
| 1H9F | Lem domain of human inner nuclear membrane protein LAP2 | solution nmr | A | — | — |
| 1H9F | Lem domain of human inner nuclear membrane protein LAP2 | solution nmr | A | — | — |
| 8FN7 | Structure of WT HIV-1 intasome bound to Dolutegravir | electron microscopy | A, B, C, D, G, H, I, J | MG, ZN, DLU | 20 (best 0.82) |
| 8FND | Structure of E138K HIV-1 intasome with Dolutegravir bound | electron microscopy | A, B, C, D, G, H, I, J | MG, ZN, DLU | 20 (best 0.78) |
| 8FNG | Structure of E138K HIV-1 intasome with Dolutegravir bound | electron microscopy | A, B, C, D, G, H, I, J | MG, ZN, DLU | 20 (best 0.80) |
| 8FNH | Structure of Q148K HIV-1 intasome with Dolutegravir bound | electron microscopy | A, B, C, D, G, H, I, J | MG, ZN, DLU | 20 (best 0.82) |
| 8FNO | Structure of E138K/G140A/Q148R HIV-1 intasome with Dolutegravir bound | electron microscopy | A, B, C, D, G, H, I, J | MG, ZN, DLU | 19 (best 0.84) |
| 8FNQ | Structure of E138K/G140A/Q148K HIV-1 intasome with 4d bound | electron microscopy | A, B, C, D, G, H, I, J | OZ1, MG, ZN | 20 (best 0.74) |
| P42166 | AlphaFold monomer V2.0 prediction for lamina-associated polypeptide 2, isoform alpha (P42166) | — | — | — |
Ligands
- MG · Magnesium ion · in 6 records
- ZN · Zinc ion · in 6 records
- DLU · (4r,12as)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6, 8-dioxo-3,4,6,8,12,12A-hexahydro-2H-pyrido[1',2':4, 5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide · in 5 records
- OZ1 · 4-amino-N-[(2,4-difluorophenyl)methyl]-1-hydroxy-6-(6-hydroxyhexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide · in 1 record
Elsewhere
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