UniProt P41743
Protein kinase C iota type (P41743)
Protein kinase C iota type (UniProt P41743), EC 2.7.11.13: 20 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P41743
- Protein
- Protein kinase C iota type
- EC
- 2.7.11.13
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 32 · 3 records with a druggable one
Structures
21 records of P41743 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1VD2 | Solution Structure of the PB1 domain of PKCiota | solution nmr | A | — | — |
| 1VD2 | Solution structure of the PB1 domain of pkciota | solution nmr | A | — | — |
| 1WMH | Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha | x-ray diffraction | A | — | — |
| 1WMH | Crystal structure of a PB1 domain complex of protein kinase C iota and PAR6 alpha | x-ray diffraction | A | — | — |
| 1ZRZ | Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota | x-ray diffraction | A | — | — |
| 1ZRZ | Crystal structure of the catalytic domain of atypical protein kinase C-iota | x-ray diffraction | A | — | — |
| 3A8W | Crystal Structure of PKCiota kinase domain | x-ray diffraction | A, B | — | — |
| 3A8W | Crystal structure of pkciota kinase domain | x-ray diffraction | A, B | — | — |
| 3A8X | Crystal Structure of PKCiota kinase domain | x-ray diffraction | A, B | — | — |
| 3A8X | Crystal structure of pkciota kinase domain | x-ray diffraction | A, B | — | — |
| 3ZH8 | A novel small molecule aPKC inhibitor | x-ray diffraction | A, B, C | — | — |
| 3ZH8 | A novel small molecule apkc inhibitor | x-ray diffraction | A, B, C | — | — |
| 5LI1 | Structure of a PAR3-inhibitory peptide bound to pkciota core kinase domain | x-ray diffraction | A | ANP, K, MG | — |
| 5LI9 | Structure of a nucleotide-bound form of PKCiota core kinase domain | x-ray diffraction | A | ACP | — |
| 5LI9 | Structure of a nucleotide-bound form of pkciota core kinase domain | x-ray diffraction | A | ACP | — |
| 5LIH | Structure of a peptide-substrate bound to PKCiota core kinase domain | x-ray diffraction | A, B | ADP, AF3, MN, SCN | 6 (best 0.80) |
| 5LIH | Structure of a peptide-substrate bound to pkciota core kinase domain | x-ray diffraction | A, B | ADP, AF3, MN, SCN | — |
| 6ILZ | Crystal structure of PKCiota in complex with inhibitor | x-ray diffraction | A, C, E, G | AFU | 19 (best 0.77) |
| 6ILZ | Crystal structure of pkciota in complex with inhibitor | x-ray diffraction | A, C, E, G | AFU | — |
| 8R3X | Crystal structure of aPKC Iota kinase domain with LLGL2 peptide | x-ray diffraction | A, B | — | 7 (best 0.80) |
| P41743 | AlphaFold monomer V2.0 prediction for protein kinase C iota type (P41743) | predicted | A | — | — |
Ligands
- ACP · Phosphomethylphosphonic acid adenylate ester · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- AF3 · Aluminum fluoride · in 2 records
- AFU · 2-amino-5-[3-(piperazin-1-yl)phenyl]-N-(pyridin-4-yl) pyridine-3-carboxamide · in 2 records
- MN · Manganese (II) ion · in 2 records
- SCN · Thiocyanate ion · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- K · Potassium ion · in 1 record
- MG · Magnesium ion · in 1 record
Experiment against prediction
- 5LI1 chain A against the predicted model P41743: TM-score 0.99, RMSD 0.74 Å
- 3A8X chain A against the predicted model P41743: TM-score 0.99, RMSD 0.78 Å
- 3A8X chain A against the predicted model P41743: TM-score 0.99, RMSD 0.78 Å
- 5LI9 chain A against the predicted model P41743: TM-score 0.98, RMSD 0.85 Å
- 5LI9 chain A against the predicted model P41743: TM-score 0.98, RMSD 0.85 Å
- 1ZRZ chain A against the predicted model P41743: TM-score 0.98, RMSD 0.89 Å
- 1ZRZ chain A against the predicted model P41743: TM-score 0.98, RMSD 0.89 Å
- 5LIH chain B against the predicted model P41743: TM-score 0.98, RMSD 0.92 Å
- 5LIH chain B against the predicted model P41743: TM-score 0.98, RMSD 0.92 Å
- 3A8W chain A against the predicted model P41743: TM-score 0.98, RMSD 0.99 Å
Elsewhere
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