UniProt P41440
BRIL-SLC19A1 chimera (P41440)
BRIL-SLC19A1 chimera (UniProt P41440): 8 experimental structures on GenesisL1, 6 ligands bound, 34 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P41440
- Protein
- BRIL-SLC19A1 chimera
- Experimental structures
- 8
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 34 · 7 records with a druggable one
Structures
8 records of P41440 in the MolNFT archive: 8 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7TX6 | Cryo-EM structure of the human reduced folate carrier in complex with methotrexate | electron microscopy | A | MTX, AJP | 4 (best 0.83) |
| 7XQ0 | Structure of hSLC19A1+3'3'-CDA | electron microscopy | A | 2BA | 3 (best 0.83) |
| 7XQ2 | Structure of hSLC19A1+2'3'-cGAMP | electron microscopy | A | 1SY | 3 (best 0.84) |
| 7XTK | Cryo-EM structure of SLC19A1 | electron microscopy | A | — | 3 (best 0.83) |
| 8HII | The BRIL-SLC19A1/Fab/Nb ternary complex | electron microscopy | A | — | 6 (best 0.84) |
| 8HIJ | The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex | electron microscopy | A | THH | 8 (best 0.83) |
| 8HIK | The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex | electron microscopy | A | TPP | 7 (best 0.85) |
| P41440 | AlphaFold monomer V2.0 prediction for reduced folate transporter (P41440) | — | — | — |
Ligands
- 1SY · cGAMP · in 1 record
- 2BA · (2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-D:3', 2'-J][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5, 10,12-tetrol 5,12-dioxide · in 1 record
- AJP · Digitonin · in 1 record
- MTX · Methotrexate · in 1 record
- THH · N-[4-({[(6S)-2-amino-4-hydroxy-5-methyl-5,6,7,8-tetrahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid · in 1 record
- TPP · Thiamine diphosphate · in 1 record
Experiment against prediction
- 8HII chain A against the predicted model P0ABE7: TM-score 0.21, RMSD 1.19 Å
- 8HIK chain A against the predicted model P0ABE7: TM-score 0.21, RMSD 1.32 Å
- 8HIJ chain A against the predicted model P0ABE7: TM-score 0.21, RMSD 1.57 Å
- 7TX6 chain A against the predicted model P0ABE7: TM-score 0.19, RMSD 4.57 Å
Elsewhere
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