UniProt P41250
Glycine--tRNA ligase (P41250)
Glycine--tRNA ligase (UniProt P41250), EC 6.1.1.14: 28 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P41250
- Protein
- Glycine--tRNA ligase
- EC
- 6.1.1.14
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 19 · 1 record with a druggable one
Structures
29 records of P41250 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2PME | The Apo crystal Structure of the glycyl-tRNA synthetase | x-ray diffraction | A | — | — |
| 2PME | The apo crystal structure of the glycyl-tRNA synthetase | x-ray diffraction | A | — | — |
| 2PMF | The crystal structure of a human glycyl-tRNA synthetase mutant | x-ray diffraction | A | — | — |
| 2PMF | The crystal structure of a human glycyl-tRNA synthetase mutant | x-ray diffraction | A | — | — |
| 2Q5H | Crystal structure of apo-wildtype Glycyl-tRNA synthetase | x-ray diffraction | A | — | — |
| 2Q5H | Crystal structure of apo-wildtype glycyl-tRNA synthetase | x-ray diffraction | A | — | — |
| 2Q5I | Crystal structure of apo S581L Glycyl-tRNA synthetase mutant | x-ray diffraction | A | — | — |
| 2Q5I | Crystal structure of apo S581L glycyl-tRNA synthetase mutant | x-ray diffraction | A | — | — |
| 2ZT5 | Crystal structure of human glycyl-trna synthetase (GLYRS) in complex with AP4A (cocrystallized with… | x-ray diffraction | A | — | — |
| 2ZT5 | Crystal structure of human glycyl-tRNA synthetase (glyrs) in complex with AP4A (cocrystallized with… | x-ray diffraction | A | — | — |
| 2ZT6 | Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP | x-ray diffraction | A | — | — |
| 2ZT6 | Crystal structure of human glycyl-tRNA synthetase (glyrs) in complex with ampcpp | x-ray diffraction | A | — | — |
| 2ZT7 | Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Glycine and ATP | x-ray diffraction | A | — | — |
| 2ZT7 | Crystal structure of human glycyl-tRNA synthetase (glyrs) in complex with glycine and ATP | x-ray diffraction | A | — | — |
| 2ZT8 | Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Gly-AMP analog | x-ray diffraction | A | — | — |
| 2ZT8 | Crystal structure of human glycyl-tRNA synthetase (glyrs) in complex with gly-AMP analog | x-ray diffraction | A | — | — |
| 2ZXF | Crystal structure of human glycyl-trna synthetase (GLYRS) in complex with AP4A (cocrystallized with… | x-ray diffraction | A | — | — |
| 2ZXF | Crystal structure of human glycyl-tRNA synthetase (glyrs) in complex with AP4A (cocrystallized with… | x-ray diffraction | A | — | — |
| 4KQE | The mutant structure of the human glycyl-tRNA synthetase E71G | x-ray diffraction | A | — | — |
| 4KQE | The mutant structure of the human glycyl-tRNA synthetase E71G | x-ray diffraction | A | — | — |
| 4KR2 | Glycyl-tRNA synthetase in complex with tRNA-Gly | x-ray diffraction | A | — | — |
| 4KR2 | Glycyl-tRNA synthetase in complex with tRNA-gly | x-ray diffraction | A | — | — |
| 4KR3 | Glycyl-tRNA synthetase mutant E71G in complex with tRNA-Gly | x-ray diffraction | A | — | — |
| 4KR3 | Glycyl-tRNA synthetase mutant E71G in complex with tRNA-gly | x-ray diffraction | A | — | — |
| 4QEI | Two distinct conformational states of GlyRS captured in crystal lattice | x-ray diffraction | A | — | — |
| 4QEI | Two distinct conformational states of glyrs captured in crystal lattice | x-ray diffraction | A | — | — |
| 5E6M | Crystal structure of human wild type GlyRS bound with tRNAGly | x-ray diffraction | A, B | GAP, SO4 | 19 (best 0.83) |
| 5E6M | Crystal structure of human wild type glyrs bound with trnagly | x-ray diffraction | A, B | — | — |
| P41250 | AlphaFold monomer V2.0 prediction for glycine--tRNA ligase (P41250) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4KR2 chain A against the predicted model P41250: TM-score 0.99, RMSD 0.67 Å
- 4KR2 chain A against the predicted model P41250: TM-score 0.99, RMSD 0.67 Å
- 4KR3 chain A against the predicted model P41250: TM-score 0.99, RMSD 0.69 Å
- 4KR3 chain A against the predicted model P41250: TM-score 0.99, RMSD 0.69 Å
- 5E6M chain A against the predicted model P41250: TM-score 0.99, RMSD 0.93 Å
- 5E6M chain A against the predicted model P41250: TM-score 0.99, RMSD 0.93 Å
- 2Q5H chain A against the predicted model P41250: TM-score 0.96, RMSD 1.75 Å
- 2Q5H chain A against the predicted model P41250: TM-score 0.96, RMSD 1.75 Å
- 2PMF chain A against the predicted model P41250: TM-score 0.96, RMSD 1.81 Å
- 2PMF chain A against the predicted model P41250: TM-score 0.96, RMSD 1.81 Å
Elsewhere
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