UniProt P41160
Leptin (P41160)
Leptin (UniProt P41160): 9 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 53 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P41160
- Protein
- Leptin
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 53 · 6 records with a druggable one
Structures
10 records of P41160 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7Z3P | Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution. | x-ray diffraction | A | CA | 1 (best 0.28) |
| 7Z3R | Crystal structure of the mouse leptin:LepR-IgCRH2 complex to 2.95 A resolution. | x-ray diffraction | A | — | 1 (best 0.40) |
| 8AVB | Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR… | electron microscopy | A | — | 5 (best 0.62) |
| 8AVC | Mouse leptin:LEP-R complex cryoEM structure (3:3 model) | electron microscopy | A, C, E | — | 13 (best 0.73) |
| 8AVD | Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local… | electron microscopy | A, C, E | — | 13 (best 0.68) |
| 8B7Q | Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in… | electron microscopy | A | — | 1 (best 0.35) |
| 8DH8 | Leptin-bound leptin receptor complex-full ECD | electron microscopy | C | — | 3 (best 0.77) |
| 8DH9 | Leptin-bound leptin receptor complex-D3-D7 | electron microscopy | C, D | — | 9 (best 0.74) |
| 8DHA | Leptin-bound leptin receptor complex- focused interaction | electron microscopy | C | — | 6 (best 0.59) |
| P41160 | AlphaFold monomer V2.0 prediction for leptin (P41160) | predicted | A | — | 1 (best 0.34) |
Ligands
- CA · Calcium ion · in 1 record
Experiment against prediction
- 8DH9 chain D against the predicted model P41160: TM-score 0.99, RMSD 0.38 Å
- 8B7Q chain A against the predicted model P41160: TM-score 0.92, RMSD 1.71 Å
- 7Z3R chain A against the predicted model P41160: TM-score 0.91, RMSD 1.81 Å
- 8AVD chain A against the predicted model P41160: TM-score 0.91, RMSD 1.79 Å
- 8AVC chain A against the predicted model P41160: TM-score 0.91, RMSD 1.75 Å
- 8DHA chain C against the predicted model P41160: TM-score 0.91, RMSD 1.58 Å
- 8DH9 chain C against the predicted model P41160: TM-score 0.91, RMSD 1.56 Å
- 8DH8 chain C against the predicted model P41160: TM-score 0.89, RMSD 1.69 Å
- 7Z3P chain A against the predicted model P41160: TM-score 0.89, RMSD 1.36 Å
- 8AVB chain A against the predicted model P41160: TM-score 0.89, RMSD 1.89 Å
Elsewhere
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