UniProt P39377
Isoaspartyl dipeptidase (P39377)
Isoaspartyl dipeptidase (UniProt P39377), EC 3.4.19.-: 18 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 65 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P39377
- Protein
- Isoaspartyl dipeptidase
- EC
- 3.4.19.-
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 65 · 12 records with a druggable one
Structures
19 records of P39377 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ONW | Crystal structure of Isoaspartyl Dipeptidase from E. coli | x-ray diffraction | A, B | ZN, CL, MG, NA | 3 (best 0.60) |
| 1ONW | Crystal structure of isoaspartyl dipeptidase from E. COLI | x-ray diffraction | A, B | ZN, CL, MG, NA | 3 (best 0.60) |
| 1ONX | Crystal structure of isoaspartyl dipeptidase from escherichia coli complexed with aspartate | x-ray diffraction | A, B | ZN, ASP | 4 (best 0.65) |
| 1ONX | Crystal structure of isoaspartyl dipeptidase from escherichia COLI complexed with aspartate | x-ray diffraction | A, B | ZN, ASP | 4 (best 0.65) |
| 1PO9 | Crytsal structure of isoaspartyl dipeptidase | x-ray diffraction | A, B | ZN | 4 (best 0.71) |
| 1PO9 | Crytsal structure of isoaspartyl dipeptidase | x-ray diffraction | A, B | ZN | 4 (best 0.71) |
| 1POJ | Isoaspartyl Dipeptidase with bound inhibitor | x-ray diffraction | A, B | ZN, AE1 | 3 (best 0.65) |
| 1POJ | Isoaspartyl dipeptidase with bound inhibitor | x-ray diffraction | A, B | ZN, AE1 | 3 (best 0.65) |
| 1POK | Crystal structure of Isoaspartyl Dipeptidase | x-ray diffraction | B, A | SO4, ZN, ASN | 2 (best 0.47) |
| 1POK | Crystal structure of isoaspartyl dipeptidase | x-ray diffraction | B, A | SO4, ZN, ASN | 2 (best 0.47) |
| 1YBQ | Crystal structure of Escherichia coli isoaspartyl dipeptidase mutant D285N complexed with… | x-ray diffraction | A, B | ZN, BDH | 3 (best 0.67) |
| 1YBQ | Crystal structure of escherichia COLI isoaspartyl dipeptidase mutant D285N complexed with… | x-ray diffraction | A, B | ZN, BDH | 3 (best 0.67) |
| 2AQO | Crystal structure of E. coli Isoaspartyl Dipeptidase Mutant E77Q | x-ray diffraction | A, B | — | — |
| 2AQO | Crystal structure of E. COLI isoaspartyl dipeptidase mutant E77Q | x-ray diffraction | A, B | ZN | 3 (best 0.55) |
| 2AQV | Crystal Structure of E. coli Isoaspartyl Dipeptidase mutant Y137F | x-ray diffraction | A, B | — | — |
| 2AQV | Crystal structure of E. COLI isoaspartyl dipeptidase mutant Y137F | x-ray diffraction | A, B | ZN | 4 (best 0.49) |
| 5LP3 | Three tetrameric rings of Isoaspartyl Dipeptidase fitted in an EM volume. | electron microscopy | B, C, D, E, A, F, G, H, I, J, K, L | — | 20 (best 0.75) |
| 5LP3 | Three tetrameric rings of isoaspartyl dipeptidase fitted in an EM volume. | electron microscopy | B, C, D, E, A, F, G, H, I, J, K, L | — | — |
| P39377 | AlphaFold monomer V2.0 prediction for isoaspartyl dipeptidase (P39377) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 14 records
- AE1 · 2-{[[(1S)-1-amino-2-carboxyethyl](dihydroxy)phosphoranyl]methyl}-4-methylpentanoic acid · in 2 records
- ASN · Asparagine · in 2 records
- ASP · Aspartic acid · in 2 records
- BDH · L-beta-aspartylhistidine · in 2 records
- CL · Chloride ion · in 2 records
- MG · Magnesium ion · in 2 records
- NA · Sodium ion · in 2 records
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 2AQV chain B against the predicted model P39377: TM-score 1.00, RMSD 0.21 Å
- 2AQV chain B against the predicted model P39377: TM-score 1.00, RMSD 0.21 Å
- 2AQO chain B against the predicted model P39377: TM-score 1.00, RMSD 0.23 Å
- 2AQO chain B against the predicted model P39377: TM-score 1.00, RMSD 0.23 Å
- 1ONW chain A against the predicted model P39377: TM-score 1.00, RMSD 0.27 Å
- 1ONW chain A against the predicted model P39377: TM-score 1.00, RMSD 0.27 Å
- 2AQV chain A against the predicted model P39377: TM-score 1.00, RMSD 0.28 Å
- 2AQV chain A against the predicted model P39377: TM-score 1.00, RMSD 0.28 Å
- 2AQO chain A against the predicted model P39377: TM-score 1.00, RMSD 0.30 Å
- 2AQO chain A against the predicted model P39377: TM-score 1.00, RMSD 0.30 Å
Elsewhere
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