UniProt P38304
Mediator of RNA polymerase II transcription subunit 8 (P38304)
Mediator of RNA polymerase II transcription subunit 8 (UniProt P38304): 19 experimental structures and 1 predicted model on GenesisL1, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P38304
- Protein
- Mediator of RNA polymerase II transcription subunit 8
- Experimental structures
- 19
- Predicted models
- 1
- Pockets
- 16 · 4 records with a druggable one
Structures
20 records of P38304 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HZS | Structure of the Mediator head submodule Med8C/18/20 | x-ray diffraction | I, J, K, L | — | — |
| 2HZS | Structure of the mediator head submodule MED8C/18/20 | x-ray diffraction | I, J, K, L | — | — |
| 3J1O | Cryo-EM map of a yeast minimal preinitiation complex interacting with the Mediator Head module | electron microscopy | J | — | — |
| 3J1O | Cryo-EM MAP of a yeast minimal preinitiation complex interacting with the mediator head module | electron microscopy | J | — | — |
| 3RJ1 | Architecture of the Mediator Head module | x-ray diffraction | C, J, Q | — | — |
| 3RJ1 | Architecture of the mediator head module | x-ray diffraction | C, J, Q | — | — |
| 4GWP | Structure of the Mediator Head Module from S. cerevisiae | x-ray diffraction | C | — | — |
| 4GWP | Structure of the mediator head module from S. cerevisiae | x-ray diffraction | C | — | — |
| 4GWQ | Structure of the Mediator Head Module from S. cerevisiae in complex with the carboxy-terminal… | x-ray diffraction | C | — | — |
| 4GWQ | Structure of the mediator head module from S. cerevisiae in complex with the carboxy-terminal… | x-ray diffraction | C | — | — |
| 4V1O | Architecture of the RNA polymerase II-Mediator core transcription initiation complex | electron microscopy | U | — | — |
| 4V1O | Architecture of the RNA polymerase II-mediator core transcription initiation complex | electron microscopy | U | — | — |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | b | — | 3 (best 0.84) |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | b | — | — |
| 5SVA | Mediator-RNA polymerase II pre-initiation complex | electron microscopy | N | — | — |
| 7UI9 | Core Mediator-PICearly (Copy A) | electron microscopy | h | — | 4 (best 0.87) |
| 7UIF | Mediator-PIC Early (Core B) | electron microscopy | h | — | 4 (best 0.84) |
| 7UIG | Mediator-PIC Early (Mediator A) | electron microscopy | h | — | 5 (best 0.81) |
| 7UIO | Mediator-PIC Early (Composite Model) | electron microscopy | Ah, Bh | — | — |
| P38304 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 8 (P38304) | predicted | A | — | — |
Experiment against prediction
- 7UIF chain h against the predicted model P38304: TM-score 0.78, RMSD 3.29 Å
- 7UI9 chain h against the predicted model P38304: TM-score 0.78, RMSD 3.29 Å
- 7UIG chain h against the predicted model P38304: TM-score 0.78, RMSD 3.29 Å
- 7UIO chain Ah against the predicted model P38304: TM-score 0.77, RMSD 3.37 Å
- 4V1O chain U against the predicted model P38304: TM-score 0.77, RMSD 2.24 Å
- 4V1O chain U against the predicted model P38304: TM-score 0.77, RMSD 2.24 Å
- 5SVA chain N against the predicted model P38304: TM-score 0.74, RMSD 2.69 Å
- 5OQM chain b against the predicted model P38304: TM-score 0.72, RMSD 2.71 Å
- 5OQM chain b against the predicted model P38304: TM-score 0.72, RMSD 2.71 Å
- 3J1O chain J against the predicted model P38304: TM-score 0.70, RMSD 2.56 Å
Elsewhere
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