UniProt P38111
Serine/threonine-protein kinase MEC1 (P38111)
Serine/threonine-protein kinase MEC1 (UniProt P38111), EC 2.7.11.1: 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 78 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P38111
- Protein
- Serine/threonine-protein kinase MEC1
- EC
- 2.7.11.1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 78 · 4 records with a druggable one
Structures
9 records of P38111 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5X6O | Intact ATR/Mec1-ATRIP/Ddc2 complex | electron microscopy | C | — | 19 (best 0.86) |
| 5X6O | Intact ATR/MEC1-ATRIP/DDC2 complex | electron microscopy | C | — | — |
| 6Z2W | Mec1-Ddc2 (F2244L mutant) in complex with Mg AMP-PNP | electron microscopy | E, F | ANP, ZN, MG | 20 (best 0.87) |
| 6Z2W | MEC1-DDC2 (F2244L mutant) in complex with mg AMP-pnp | electron microscopy | E, F | ANP, ZN, MG | — |
| 6Z2X | MEC1-DDC2 (F2244L mutant) in complex with mg AMP-pnp (state II) | electron microscopy | E, F | ANP, ZN, MG | — |
| 6Z3A | MEC1-DDC2 (wild-type) in complex with AMP-pnp | electron microscopy | F, E | ANP, ZN | — |
| 7WZR | Cryo-EM structure of Mec1-HU | electron microscopy | C, F | — | 20 (best 0.79) |
| 7WZW | Cryo-EM structure of MEC1-DDC2-MMS | electron microscopy | F, E | — | 19 (best 0.86) |
| P38111 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase MEC1 (P38111) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6Z2X chain E against the predicted model P38111: TM-score 0.97, RMSD 2.50 Å
- 6Z2X chain F against the predicted model P38111: TM-score 0.97, RMSD 2.50 Å
- 6Z2W chain E against the predicted model P38111: TM-score 0.97, RMSD 2.53 Å
- 6Z2W chain E against the predicted model P38111: TM-score 0.97, RMSD 2.53 Å
- 6Z2W chain F against the predicted model P38111: TM-score 0.97, RMSD 2.53 Å
- 6Z2W chain F against the predicted model P38111: TM-score 0.97, RMSD 2.53 Å
- 6Z3A chain F against the predicted model P38111: TM-score 0.95, RMSD 3.61 Å
- 6Z3A chain E against the predicted model P38111: TM-score 0.95, RMSD 3.61 Å
- 5X6O chain C against the predicted model P38111: TM-score 0.94, RMSD 3.43 Å
- 5X6O chain C against the predicted model P38111: TM-score 0.94, RMSD 3.43 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.