UniProt P36969
Phospholipid hydroperoxide glutathione peroxidase (P36969)
Phospholipid hydroperoxide glutathione peroxidase (UniProt P36969), EC 1.11.1.12: 32 experimental structures on GenesisL1, 10 ligands bound, 3 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P36969
- Protein
- Phospholipid hydroperoxide glutathione peroxidase
- EC
- 1.11.1.12
- Experimental structures
- 32
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 3 · 0 records with a druggable one
Structures
32 records of P36969 in the MolNFT archive: 32 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2GS3 | Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4) | x-ray diffraction | A | — | — |
| 2GS3 | Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4) | x-ray diffraction | A | — | — |
| 2OBI | Crystal structure of the Selenocysteine to Cysteine Mutant of human phospholipid hydroperoxide… | x-ray diffraction | A | — | — |
| 2OBI | Crystal structure of the selenocysteine to cysteine mutant of human phospholipid hydroperoxide… | x-ray diffraction | A | — | — |
| 5H5Q | Crystal structure of human GPX4 in complex with GXpep-1 | x-ray diffraction | A | — | — |
| 5H5Q | Crystal structure of human GPX4 in complex with gxpep-1 | x-ray diffraction | A | — | — |
| 5H5R | Crystal structure of human GPX4 in complex with GXpep-2 | x-ray diffraction | A | — | — |
| 5H5R | Crystal structure of human GPX4 in complex with gxpep-2 | x-ray diffraction | A | — | — |
| 5H5S | Crystal structure of human GPX4 in complex with GXpep-3 | x-ray diffraction | A | — | — |
| 5H5S | Crystal structure of human GPX4 in complex with gxpep-3 | x-ray diffraction | A | — | — |
| 6ELW | High resolution structure of selenocysteine containing human GPX4 | x-ray diffraction | A | CL | — |
| 6ELW | High resolution structure of selenocysteine containing human GPX4 | x-ray diffraction | A | CL | — |
| 6HKQ | Human GPX4 in complex with covalent Inhibitor ML162 (S enantiomer) | x-ray diffraction | A | G9N, SO4 | — |
| 6HKQ | Human GPX4 in complex with covalent inhibitor ML162 (S enantiomer) | x-ray diffraction | A | G9N, SO4 | — |
| 6HN3 | wildtype form (apo) of human GPX4 with Se-Cys46 | x-ray diffraction | A | CL | — |
| 6HN3 | Wildtype form (apo) of human GPX4 with se-CYS46 | x-ray diffraction | A | CL | — |
| 7L8K | Crystal structure of human GPX4-U46C | x-ray diffraction | A | PO4 | — |
| 7L8K | Crystal structure of human GPX4-U46C | x-ray diffraction | A | PO4 | — |
| 7L8L | Crystal structure of human R152H GPX4-U46C | x-ray diffraction | A | SCN | — |
| 7L8L | Crystal structure of human R152H GPX4-U46C | x-ray diffraction | A | SCN | — |
| 7L8M | Crystal structure of human GPX4-U46C mutant K48L | x-ray diffraction | A | — | — |
| 7L8M | Crystal structure of human GPX4-U46C mutant K48L | x-ray diffraction | A | — | — |
| 7L8Q | Crystal structure of human GPX4-U46C with oxidized Cys-46 | x-ray diffraction | A | — | — |
| 7L8Q | Crystal structure of human GPX4-U46C with oxidized cys-46 | x-ray diffraction | A | — | — |
| 7L8R | Crystal structure of human GPX4-U46C mutant K48A | x-ray diffraction | A, B | SCN | — |
| 7L8R | Crystal structure of human GPX4-U46C mutant K48A | x-ray diffraction | A, B | SCN | — |
| 7U4I | Crystal structure of human GPX4-U46C-R152H in complex with CDS9 | x-ray diffraction | A, B | L9U, SCN | 2 (best 0.46) |
| 7U4J | Crystal structure of human GPX4-U46C-R152H in complex with TMT10 | x-ray diffraction | A | 8NB, SCN | — |
| 7U4K | Crystal structure of human GPX4-U46C-R152H in complex with ML162 | x-ray diffraction | A | L9C | — |
| 7U4M | Crystal structure of human GPX4-U46C in complex with LOC1886 | x-ray diffraction | A | LBI | — |
| 7U4N | Crystal structure of human GPX4-U46C in complex with RSL3 | x-ray diffraction | A, B | L8X | 1 (best 0.36) |
| 8Q8N | Crystal structure of human GPX4-U46C-I129S-L130S | x-ray diffraction | A | — | — |
Ligands
- SCN · Thiocyanate ion · in 6 records
- CL · Chloride ion · in 4 records
- G9N · (2~{S})-2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-~{N}-(2-phenylethyl)-2-thiophen-2-yl-ethanamide · in 2 records
- PO4 · Phosphate ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- 8NB · ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide · in 1 record
- L8X · methyl (1S,3R)-2-(chloroacetyl)-1-[4-(methoxycarbonyl)phenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate · in 1 record
- L9C · 2-chloro-N-(3-chloro-4-methoxyphenyl)-N-[(1R)-2-oxo-2-[(2-phenylethyl)amino]-1-(thiophen-2-yl)ethyl]acetamide · in 1 record
- L9U · 2-bromo-N-[(thiophen-2-yl)methyl]acetamide · in 1 record
- LBI · 4-methoxy-1H-indole-2-carbaldehyde · in 1 record
Elsewhere
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