UniProt P35991
Tyrosine-protein kinase BTK (P35991)
Tyrosine-protein kinase BTK (UniProt P35991), EC 2.7.10.2: 4 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P35991
- Protein
- Tyrosine-protein kinase BTK
- EC
- 2.7.10.2
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 6 · 1 record with a druggable one
Structures
5 records of P35991 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XI2 | Crystal Structure of an auto-inhibited form of Bruton's Tryrosine Kinase | x-ray diffraction | A | — | — |
| 4XI2 | Crystal structure of an auto-inhibited form of BRUTON'S tryrosine kinase | x-ray diffraction | A | — | — |
| 8FF0 | Structure of BTK kinase domain with the second-generation inhibitor tirabrutinib | x-ray diffraction | A | 7GB | — |
| 8S9F | Crystal structure of the kinase domain of Bruton's Tyrosine Kinase bound to dasatinib | x-ray diffraction | B, A | 1N1 | 6 (best 0.68) |
| P35991 | AlphaFold monomer V2.0 prediction for tyrosine-protein kinase btk (P35991) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8FF0 chain A against the predicted model P35991: TM-score 0.99, RMSD 0.64 Å
- 8S9F chain A against the predicted model P35991: TM-score 0.87, RMSD 2.21 Å
- 8S9F chain B against the predicted model P35991: TM-score 0.87, RMSD 2.22 Å
- 4XI2 chain A against the predicted model P35991: TM-score 0.72, RMSD 1.17 Å
- 4XI2 chain A against the predicted model P35991: TM-score 0.72, RMSD 1.17 Å
Elsewhere
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