UniProt P35520
Cystathionine beta-synthase (P35520)
Cystathionine beta-synthase (UniProt P35520), EC 4.2.1.22: 27 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 153 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P35520
- Protein
- Cystathionine beta-synthase
- EC
- 4.2.1.22
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 153 · 8 records with a druggable one
Structures
28 records of P35520 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JBQ | Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate dependent… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1JBQ | Structure of human cystathionine beta-synthase: a unique pyridoxal 5'- phosphate dependent… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1M54 | Cystathionine-beta synthase: reduced vicinal thiols | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1M54 | Cystathionine-beta synthase: reduced vicinal thiols | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4COO | Crystal structure of human cystathionine beta-synthase (delta516-525) at 2.0 angstrom resolution | x-ray diffraction | A, B | — | — |
| 4COO | Crystal structure of human cystathionine beta-synthase (DELTA516-525) at 2.0 ångström resolution | x-ray diffraction | A, B | — | — |
| 4L0D | Crystal structure of delta516-525 human cystathionine beta-synthase containing C-terminal 6xHis-tag | x-ray diffraction | A, B | — | — |
| 4L0D | Crystal structure of DELTA516-525 human cystathionine beta-synthase containing C-terminal 6XHIS-tag | x-ray diffraction | A, B | — | — |
| 4L27 | Crystal structure of delta1-39 and delta516-525 human cystathionine beta-synthase D444N mutant… | x-ray diffraction | B, D, A, C | — | — |
| 4L27 | Crystal structure of DELTA1-39 and DELTA516-525 human cystathionine beta-synthase D444N mutant… | x-ray diffraction | B, D, A, C | — | — |
| 4L28 | Crystal structure of delta516-525 human cystathionine beta-synthase D444N mutant containing… | x-ray diffraction | A, B, C, D | — | — |
| 4L28 | Crystal structure of DELTA516-525 human cystathionine beta-synthase D444N mutant containing… | x-ray diffraction | A, B, C, D | — | — |
| 4L3V | Crystal structure of delta516-525 human cystathionine beta-synthase | x-ray diffraction | B, A, C | — | — |
| 4L3V | Crystal structure of DELTA516-525 human cystathionine beta-synthase | x-ray diffraction | B, A, C | — | — |
| 4PCU | Crystal structure of delta516-525 E201S human cystathionine beta-synthase with AdoMet | x-ray diffraction | A, B | — | — |
| 4PCU | Crystal structure of DELTA516-525 E201S human cystathionine beta- synthase with adomet | x-ray diffraction | A, B | — | — |
| 4UUU | 1.7 A resolution structure of human cystathionine beta-synthase regulatory domain (del 516-525) in… | x-ray diffraction | A, B | — | — |
| 4UUU | 1.7 a resolution structure of human cystathionine beta-synthase regulatory domain (del 516-525) in… | x-ray diffraction | A, B | — | — |
| 5MMS | Human cystathionine beta-synthase (CBS) p.P49L delta409-551 variant | x-ray diffraction | A, B, C, D, E, F | HEM, PLP, NA | 20 (best 0.83) |
| 5MMS | Human cystathionine beta-synthase (cbs) P.P49L DELTA409-551 variant | x-ray diffraction | A, B, C, D, E, F | HEM, PLP, NA | — |
| 7QGT | Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with AOAA. | x-ray diffraction | A, B | HEM, PLP, IK2 | 15 (best 0.78) |
| 8S5H | Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, basal state, helical… | electron microscopy | A, B, C, D, E, F, G, H | HEM | 20 (best 0.77) |
| 8S5I | Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, basal state, single… | electron microscopy | A, B, C, D, E, F | HEM | 20 (best 0.79) |
| 8S5J | Full-length human cystathionine beta-synthase, basal state, helical reconstruction | electron microscopy | A, B, C, D, E, F, G, H, I, J | HEM | 20 (best 0.76) |
| 8S5K | Full-length human cystathionine beta-synthase, basal state, single particle reconstruction | electron microscopy | A, B, C, D, E, F, G, H | HEM | 20 (best 0.80) |
| 8S5M | Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, SAM bound, activated… | electron microscopy | A, B, C, D, E, F, G, H, I, J | SAM | 18 (best 0.76) |
| 8STW | K384N HUMAN CYSTATHIONINE BETA-SYNTHASE (delta 411-551) | x-ray diffraction | A, B, C, D, E, F | PLP, HEM | 20 (best 0.82) |
| P35520 | AlphaFold monomer V2.0 prediction for cystathionine beta-synthase (P35520) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5MMS chain F against the predicted model P35520: TM-score 0.99, RMSD 0.70 Å
- 5MMS chain F against the predicted model P35520: TM-score 0.99, RMSD 0.70 Å
- 8STW chain B against the predicted model P35520: TM-score 0.99, RMSD 0.73 Å
- 5MMS chain C against the predicted model P35520: TM-score 0.99, RMSD 0.73 Å
- 5MMS chain C against the predicted model P35520: TM-score 0.99, RMSD 0.73 Å
- 8STW chain E against the predicted model P35520: TM-score 0.99, RMSD 0.77 Å
- 5MMS chain D against the predicted model P35520: TM-score 0.99, RMSD 0.78 Å
- 5MMS chain D against the predicted model P35520: TM-score 0.99, RMSD 0.78 Å
- 8STW chain A against the predicted model P35520: TM-score 0.99, RMSD 0.79 Å
- 8STW chain D against the predicted model P35520: TM-score 0.99, RMSD 0.80 Å
Elsewhere
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