UniProt P35372
Mu-type opioid receptor (P35372)
Mu-type opioid receptor (UniProt P35372): 8 experimental structures on GenesisL1, 6 ligands bound, 40 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P35372
- Protein
- Mu-type opioid receptor
- Experimental structures
- 8
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 40 · 7 records with a druggable one
Structures
8 records of P35372 in the MolNFT archive: 8 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8EF5 | Fentanyl-bound mu-opioid receptor-Gi complex | electron microscopy | R, M | 7V7, CLR | 6 (best 0.81) |
| 8EF6 | Morphine-bound mu-opioid receptor-Gi complex | electron microscopy | R, M | MOI, CLR | 7 (best 0.83) |
| 8EFB | Oliceridine-bound mu-opioid receptor-Gi complex | electron microscopy | R | WH2 | 4 (best 0.78) |
| 8EFL | SR17018-bound mu-opioid receptor-Gi complex | electron microscopy | R, M | WH9, CLR | 6 (best 0.80) |
| 8EFQ | DAMGO-bound mu-opioid receptor-Gi complex | electron microscopy | R | ETA | 3 (best 0.65) |
| 8F7Q | Gi bound mu-opioid receptor in complex with beta-endorphin | electron microscopy | R, M | CLR | 9 (best 0.80) |
| 8K9K | Full agonist-bound mu-type opioid receptor-G protein complex | electron microscopy | R | — | 5 (best 0.70) |
| P35372 | AlphaFold monomer V2.0 prediction for mu-type opioid receptor (P35372) | — | — | — |
Ligands
- CLR · Cholesterol · in 4 records
- 7V7 · N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide · in 1 record
- ETA · Ethanolamine · in 1 record
- MOI · (7r,7as,12bs)-3-methyl-2,3,4,4A,7,7A-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol · in 1 record
- WH2 · N-[(3-methoxythiophen-2-yl)methyl]-2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethan-1-amine · in 1 record
- WH9 · 5,6-dichloro-1-{1-[(4-chlorophenyl)methyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one · in 1 record
Experiment against prediction
- 8K9K chain R against the predicted model P0ABE7: TM-score 0.26, RMSD 4.32 Å
Elsewhere
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