UniProt P35367
Histamine H1 receptor,Soluble cytochrome b562 (P35367)
Histamine H1 receptor,Soluble cytochrome b562 (UniProt P35367): 5 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P35367
- Protein
- Histamine H1 receptor,Soluble cytochrome b562
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 8 · 2 records with a druggable one
Structures
6 records of P35367 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3RZE | Structure of the human histamine H1 receptor in complex with doxepin | x-ray diffraction | A | — | — |
| 3RZE | Structure of the human histamine H1 receptor in complex with doxepin | x-ray diffraction | A | — | — |
| 7DFL | Cryo-EM structure of histamine H1 receptor gq complex | electron microscopy | R | HSM | — |
| 8X5Y | CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with astemizole | electron microscopy | B | XB7 | 4 (best 0.78) |
| 8X63 | CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with mepyramine | electron microscopy | B | Y5E | 4 (best 0.80) |
| P35367 | AlphaFold monomer V2.0 prediction for histamine H1 receptor (P35367) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8X5Y chain B against the predicted model P35367: TM-score 0.97, RMSD 1.31 Å
- 8X63 chain B against the predicted model P35367: TM-score 0.95, RMSD 1.49 Å
- 7DFL chain R against the predicted model P35367: TM-score 0.91, RMSD 2.12 Å
- 3RZE chain A against the predicted model P35367: TM-score 0.65, RMSD 3.70 Å
- 3RZE chain A against the predicted model P35367: TM-score 0.65, RMSD 3.70 Å
- 8X63 chain B against the predicted model P0ABE7: TM-score 0.30, RMSD 3.64 Å
- 8X5Y chain B against the predicted model P0ABE7: TM-score 0.29, RMSD 4.21 Å
Elsewhere
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