UniProt P34162
Mediator of RNA polymerase II transcription subunit 20 (P34162)
Mediator of RNA polymerase II transcription subunit 20 (UniProt P34162): 23 experimental structures and 1 predicted model on GenesisL1, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P34162
- Protein
- Mediator of RNA polymerase II transcription subunit 20
- Experimental structures
- 23
- Predicted models
- 1
- Pockets
- 16 · 7 records with a druggable one
Structures
24 records of P34162 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HZM | Structure of the Mediator head subcomplex Med18/20 | x-ray diffraction | A, C, E, G | — | — |
| 2HZM | Structure of the mediator head subcomplex MED18/20 | x-ray diffraction | A, C, E, G | — | — |
| 2HZS | Structure of the Mediator head submodule Med8C/18/20 | x-ray diffraction | A, C, E, G | — | — |
| 2HZS | Structure of the mediator head submodule MED8C/18/20 | x-ray diffraction | A, C, E, G | — | — |
| 3J1O | Cryo-EM map of a yeast minimal preinitiation complex interacting with the Mediator Head module | electron microscopy | M | — | — |
| 3J1O | Cryo-EM MAP of a yeast minimal preinitiation complex interacting with the mediator head module | electron microscopy | M | — | — |
| 3RJ1 | Architecture of the Mediator Head module | x-ray diffraction | F, M, T | — | — |
| 3RJ1 | Architecture of the mediator head module | x-ray diffraction | F, M, T | — | — |
| 4GWP | Structure of the Mediator Head Module from S. cerevisiae | x-ray diffraction | F | — | — |
| 4GWP | Structure of the mediator head module from S. cerevisiae | x-ray diffraction | F | — | — |
| 4GWQ | Structure of the Mediator Head Module from S. cerevisiae in complex with the carboxy-terminal… | x-ray diffraction | F | — | — |
| 4GWQ | Structure of the mediator head module from S. cerevisiae in complex with the carboxy-terminal… | x-ray diffraction | F | — | — |
| 4V1O | Architecture of the RNA polymerase II-Mediator core transcription initiation complex | electron microscopy | Y | — | — |
| 4V1O | Architecture of the RNA polymerase II-mediator core transcription initiation complex | electron microscopy | Y | — | — |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | f | — | 3 (best 0.84) |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | f | — | — |
| 5SVA | Mediator-RNA Polymerase II Pre-Initiation Complex | electron microscopy | R | — | 2 (best 0.80) |
| 5SVA | Mediator-RNA polymerase II pre-initiation complex | electron microscopy | R | — | — |
| 7UI9 | Core Mediator-PICearly (Copy A) | electron microscopy | t | — | 3 (best 0.82) |
| 7UIF | Mediator-PIC Early (Core B) | electron microscopy | t | — | 3 (best 0.83) |
| 7UIG | Mediator-PIC Early (Mediator A) | electron microscopy | t | — | 1 (best 0.82) |
| 7UIO | Mediator-PIC Early (Composite Model) | electron microscopy | At, Bt | — | 2 (best 0.87) |
| 8CEO | Yeast RNA polymerase II transcription pre-initiation complex with core Mediator and the +1… | electron microscopy | f | — | 2 (best 0.83) |
| P34162 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 20… | predicted | A | — | — |
Experiment against prediction
- 4V1O chain Y against the predicted model P34162: TM-score 0.98, RMSD 0.87 Å
- 4V1O chain Y against the predicted model P34162: TM-score 0.98, RMSD 0.87 Å
- 2HZS chain A against the predicted model P34162: TM-score 0.98, RMSD 0.87 Å
- 2HZS chain A against the predicted model P34162: TM-score 0.98, RMSD 0.87 Å
- 5OQM chain f against the predicted model P34162: TM-score 0.97, RMSD 0.91 Å
- 5OQM chain f against the predicted model P34162: TM-score 0.97, RMSD 0.91 Å
- 2HZS chain C against the predicted model P34162: TM-score 0.97, RMSD 0.99 Å
- 2HZS chain C against the predicted model P34162: TM-score 0.97, RMSD 0.99 Å
- 7UI9 chain t against the predicted model P34162: TM-score 0.97, RMSD 1.02 Å
- 7UIF chain t against the predicted model P34162: TM-score 0.97, RMSD 1.02 Å
Elsewhere
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