UniProt P32570
Mediator of RNA polymerase II transcription subunit 22 (P32570)
Mediator of RNA polymerase II transcription subunit 22 (UniProt P32570): 21 experimental structures and 1 predicted model on GenesisL1, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P32570
- Protein
- Mediator of RNA polymerase II transcription subunit 22
- Experimental structures
- 21
- Predicted models
- 1
- Pockets
- 14 · 4 records with a druggable one
Structures
22 records of P32570 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J1O | Cryo-EM map of a yeast minimal preinitiation complex interacting with the Mediator Head module | electron microscopy | K | — | — |
| 3J1O | Cryo-EM MAP of a yeast minimal preinitiation complex interacting with the mediator head module | electron microscopy | K | — | — |
| 3R84 | Structure of the Mediator head subcomplex Med11/22 | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X | — | — |
| 3R84 | Structure of the mediator head subcomplex MED11/22 | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X | — | — |
| 3RJ1 | Architecture of the Mediator Head module | x-ray diffraction | D, K, R | — | — |
| 3RJ1 | Architecture of the mediator head module | x-ray diffraction | D, K, R | — | — |
| 4GWP | Structure of the Mediator Head Module from S. cerevisiae | x-ray diffraction | D | — | — |
| 4GWP | Structure of the mediator head module from S. cerevisiae | x-ray diffraction | D | — | — |
| 4GWQ | Structure of the Mediator Head Module from S. cerevisiae in complex with the carboxy-terminal… | x-ray diffraction | D | — | — |
| 4GWQ | Structure of the mediator head module from S. cerevisiae in complex with the carboxy-terminal… | x-ray diffraction | D | — | — |
| 4H62 | Structure of the Saccharomyces cerevisiae Mediator subcomplex Med17C/Med11C/Med22C | x-ray diffraction | V | — | — |
| 4H62 | Structure of the saccharomyces cerevisiae mediator subcomplex MED17C/MED11C/MED22C | x-ray diffraction | V | — | — |
| 4V1O | Architecture of the RNA polymerase II-Mediator core transcription initiation complex | electron microscopy | Z | — | — |
| 4V1O | Architecture of the RNA polymerase II-mediator core transcription initiation complex | electron microscopy | Z | — | — |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | g | — | 2 (best 0.82) |
| 5OQM | Structure of yeast transcription pre-initiation complex with tfiih and core mediator | electron microscopy | g | — | — |
| 5SVA | Mediator-RNA polymerase II pre-initiation complex | electron microscopy | S | — | — |
| 7UIF | Mediator-PIC Early (Core B) | electron microscopy | v | — | 4 (best 0.84) |
| 7UIG | Mediator-PIC Early (Mediator A) | electron microscopy | v | — | 6 (best 0.81) |
| 7UIO | Mediator-PIC Early (Composite Model) | electron microscopy | Av, Bv | — | 2 (best 0.81) |
| 8CEO | Yeast RNA polymerase II transcription pre-initiation complex with core Mediator and the +1… | electron microscopy | g | — | — |
| P32570 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 22… | predicted | A | — | — |
Experiment against prediction
- 3R84 chain J against the predicted model P32570: TM-score 0.88, RMSD 1.87 Å
- 3R84 chain J against the predicted model P32570: TM-score 0.88, RMSD 1.87 Å
- 3R84 chain B against the predicted model P32570: TM-score 0.88, RMSD 1.87 Å
- 3R84 chain B against the predicted model P32570: TM-score 0.88, RMSD 1.87 Å
- 3R84 chain D against the predicted model P32570: TM-score 0.88, RMSD 1.89 Å
- 3R84 chain D against the predicted model P32570: TM-score 0.88, RMSD 1.89 Å
- 3R84 chain F against the predicted model P32570: TM-score 0.88, RMSD 1.85 Å
- 3R84 chain F against the predicted model P32570: TM-score 0.88, RMSD 1.85 Å
- 3R84 chain N against the predicted model P32570: TM-score 0.88, RMSD 1.89 Å
- 3R84 chain N against the predicted model P32570: TM-score 0.88, RMSD 1.89 Å
Elsewhere
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