UniProt P31327
Carbamoyl-phosphate synthase [ammonia], mitochondrial (P31327)
Carbamoyl-phosphate synthase [ammonia], mitochondrial (UniProt P31327), EC 6.3.4.16: 12 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 41 pockets. Binding sites, druggability and experiment against…
- UniProt
- P31327
- Protein
- Carbamoyl-phosphate synthase [ammonia], mitochondrial
- EC
- 6.3.4.16
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 41 · 3 records with a druggable one
Structures
13 records of P31327 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2YVQ | Crystal structure of MGS domain of carbamoyl-phosphate synthetase from homo sapiens | x-ray diffraction | A | — | — |
| 2YVQ | Crystal structure of mgs domain of carbamoyl-phosphate synthetase from homo sapiens | x-ray diffraction | A | — | — |
| 5DOT | Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form | x-ray diffraction | A, B | NI | — |
| 5DOT | Crystal structure of human carbamoyl phosphate synthetase I (CPS1), apo form | x-ray diffraction | A, B | — | — |
| 5DOU | Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form | x-ray diffraction | A, B, C, D | NI, MG, K, PO4, ADP, NLG | — |
| 5DOU | Crystal structure of human carbamoyl phosphate synthetase I (CPS1), ligand-bound form | x-ray diffraction | A, B, C, D | — | — |
| 5OJO | Sirtuin 5 from Danio rerio in complex with 3-hydroxy-3-methylglutaryl-CPS1 peptide | x-ray diffraction | C | — | 1 (best 0.57) |
| 5OJO | Sirtuin 5 from danio rerio in complex with 3-hydroxy-3-methylglutaryl- CPS1 peptide | x-ray diffraction | C | — | — |
| 6UEL | CPS1 bound to allosteric inhibitor H3B-193 | x-ray diffraction | A, B | ZN, Q5A | 20 (best 0.85) |
| 6UEL | CPS1 bound to allosteric inhibitor H3B-193 | x-ray diffraction | A, B | ZN, Q5A | — |
| 6W2J | CPS1 bound to allosteric inhibitor H3B-374 | x-ray diffraction | A, B | 374, ZN | 20 (best 0.84) |
| 6W2J | CPS1 bound to allosteric inhibitor H3B-374 | x-ray diffraction | A, B | 374, ZN | — |
| P31327 | AlphaFold monomer V2.0 prediction for carbamoyl-phosphate synthase [ammonia], mitochondrial (P31327) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 4 records
- 374 · (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone · in 2 records
- NI · Nickel (II) ion · in 2 records
- Q5A · N~1~-[(4-fluorophenyl)methyl]-N~1~-methyl-N~4~-(4-methyl-1,3-thiazol-2-yl)piperidine-1,4-dicarboxamide · in 2 records
- ADP · Adenosine-5'-diphosphate · in 1 record
- CL · Chloride ion · in 1 record
- K · Potassium ion · in 1 record
- MG · Magnesium ion · in 1 record
- NLG · N-acetyl-L-glutamate · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 5DOU chain A against the predicted model P31327: TM-score 1.00, RMSD 0.36 Å
- 5DOU chain A against the predicted model P31327: TM-score 1.00, RMSD 0.36 Å
- 5DOU chain D against the predicted model P31327: TM-score 1.00, RMSD 0.42 Å
- 5DOU chain D against the predicted model P31327: TM-score 1.00, RMSD 0.42 Å
- 5DOU chain C against the predicted model P31327: TM-score 1.00, RMSD 0.43 Å
- 5DOU chain C against the predicted model P31327: TM-score 1.00, RMSD 0.43 Å
- 5DOU chain B against the predicted model P31327: TM-score 1.00, RMSD 0.51 Å
- 5DOU chain B against the predicted model P31327: TM-score 1.00, RMSD 0.51 Å
- 5DOT chain B against the predicted model P31327: TM-score 0.98, RMSD 1.91 Å
- 5DOT chain B against the predicted model P31327: TM-score 0.98, RMSD 1.91 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.