UniProt P29460
Interleukin-12 subunit beta (P29460)
Interleukin-12 subunit beta (UniProt P29460): 29 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P29460
- Protein
- Interleukin-12 subunit beta
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 10 · 3 records with a druggable one
Structures
30 records of P29460 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F42 | The P40 domain of human interleukin-12 | x-ray diffraction | A | — | — |
| 1F42 | The P40 domain of human interleukin-12 | x-ray diffraction | A | — | — |
| 1F45 | Human interleukin-12 | x-ray diffraction | A | — | — |
| 1F45 | Human interleukin-12 | x-ray diffraction | A | — | — |
| 3D85 | Crystal structure of IL-23 in complex with neutralizing FAB | x-ray diffraction | D | — | — |
| 3D85 | Crystal structure of il-23 in complex with neutralizing Fab | x-ray diffraction | D | — | — |
| 3D87 | Crystal structure of Interleukin-23 | x-ray diffraction | B, D | — | — |
| 3D87 | Crystal structure of interleukin-23 | x-ray diffraction | B, D | — | — |
| 3DUH | Structure of Interleukin-23 | x-ray diffraction | A, B | — | — |
| 3DUH | Structure of interleukin-23 | x-ray diffraction | A, B | — | — |
| 3HMX | Crystal structure of ustekinumab FAB/IL-12 complex | x-ray diffraction | A | — | — |
| 3HMX | Crystal structure of ustekinumab FAB/IL-12 complex | x-ray diffraction | A | — | — |
| 3QWR | Crystal structure of IL-23 in complex with an adnectin | x-ray diffraction | A | — | — |
| 3QWR | Crystal structure of il-23 in complex with an adnectin | x-ray diffraction | A | — | — |
| 4GRW | Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs) | x-ray diffraction | B, D | — | — |
| 4GRW | Structure of a complex of human il-23 with 3 nanobodies (llama vhhs) | x-ray diffraction | B, D | — | — |
| 5MJ3 | Interleukin-23 complex with an antagonistic alphabody, crystal form 1 | x-ray diffraction | A | NAG, BMA, NA | 3 (best 0.74) |
| 5MJ3 | Interleukin-23 complex with an antagonistic alphabody, crystal form 1 | x-ray diffraction | A | NAG, NA | — |
| 5MJ4 | Interleukin-23 complex with an antagonistic alphabody, crystal form 2 | x-ray diffraction | A | NAG, BMA | 3 (best 0.74) |
| 5MJ4 | Interleukin-23 complex with an antagonistic alphabody, crystal form 2 | x-ray diffraction | A | NAG | — |
| 5MXA | Structure of unbound Interleukin-23 | x-ray diffraction | A | NAG, BMA, MAN | — |
| 5MXA | Structure of unbound interleukin-23 | x-ray diffraction | A | NAG, BMA, MAN | — |
| 5MZV | IL-23:IL-23R:Nb22E11 complex | x-ray diffraction | A | NAG, BMA, MAN, CL, NA | — |
| 5MZV | Il-23:IL-23R:NB22E11 complex | x-ray diffraction | A | NAG, BMA, MAN, CL, NA | — |
| 5NJD | Structure of Interleukin 23 in complex with Briakinumab FAb | x-ray diffraction | A, C, E, G, I, K | NAG, SO4 | — |
| 5NJD | Structure of interleukin 23 in complex with briakinumab Fab | x-ray diffraction | A, C, E, G, I, K | NAG, SO4 | — |
| 6UIB | Crystal structure of IL23 bound to peptide 23-652 | x-ray diffraction | B | NAG | — |
| 6WDQ | IL23/IL23R/IL12Rb1 signaling complex | x-ray diffraction | A | NAG | 4 (best 0.83) |
| 6WDQ | IL23/IL23R/IL12RB1 signaling complex | x-ray diffraction | A | NAG | — |
| P29460 | AlphaFold monomer V2.0 prediction for interleukin-12 subunit beta (P29460) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5MJ3 chain A against the predicted model P29460: TM-score 0.99, RMSD 0.65 Å
- 5MJ3 chain A against the predicted model P29460: TM-score 0.99, RMSD 0.65 Å
- 5MJ4 chain A against the predicted model P29460: TM-score 0.99, RMSD 0.71 Å
- 5MJ4 chain A against the predicted model P29460: TM-score 0.99, RMSD 0.71 Å
- 6UIB chain B against the predicted model P29460: TM-score 0.99, RMSD 0.69 Å
- 4GRW chain D against the predicted model P29460: TM-score 0.99, RMSD 0.73 Å
- 4GRW chain D against the predicted model P29460: TM-score 0.99, RMSD 0.73 Å
- 5NJD chain E against the predicted model P29460: TM-score 0.98, RMSD 0.92 Å
- 5NJD chain E against the predicted model P29460: TM-score 0.98, RMSD 0.92 Å
- 5NJD chain C against the predicted model P29460: TM-score 0.98, RMSD 0.92 Å
Elsewhere
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