UniProt P28796
Tryptophanase (P28796)
Tryptophanase (UniProt P28796), EC 4.1.99.1: 7 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 64 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P28796
- Protein
- Tryptophanase
- EC
- 4.1.99.1
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 64 · 4 records with a druggable one
Structures
8 records of P28796 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AX4 | Tryptophanase from proteus vulgaris | x-ray diffraction | A, B, C, D | — | — |
| 1AX4 | Tryptophanase from proteus vulgaris | x-ray diffraction | A, B, C, D | — | — |
| 5W19 | Tryptophan indole-lyase complex with oxindolyl-L-alanine | x-ray diffraction | A, B, C, D | K, 9TD | — |
| 5W1B | Tryptophan indole-lyase | x-ray diffraction | A, B, C, D | K | — |
| 8V4A | Proteus vulgaris tryptophan indole-lyase complexed with L-ethionine | x-ray diffraction | A, B, C, D | K, YAE, YAR | 20 (best 0.80) |
| 8V6P | Proteus vulgaris tryptophan indole-lyase complexed with 7-aza-L-tryptophan | x-ray diffraction | A, B, C, D | K, A1ACN, A1ABZ | 20 (best 0.81) |
| 9BNJ | Proteus vulgaris tryptophan indole-lyase aminoacrylate complex with benzimidazole | x-ray diffraction | A, B, C, D | K, BZI, 0JO, CL | 20 (best 0.81) |
| P28796 | AlphaFold monomer V2.0 prediction for tryptophanase (P28796) | predicted | A | — | 4 (best 0.74) |
Ligands
- K · Potassium ion · in 5 records
- 0JO · 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid · in 1 record
- 9TD · 1-carboxy-1-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]azaniumyl}-2-[(3R)-2-oxo-2,3-dihydro-1H-indol-3-yl]ethan-1-ide · in 1 record
- A1ABZ · (2E)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid · in 1 record
- A1ACN · (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-L-alanine · in 1 record
- BZI · Benzimidazole · in 1 record
- CL · Chloride ion · in 1 record
- YAE · (E)-S-ethyl-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-homocysteine · in 1 record
- YAR · (2E)-4-(ethylsulfanyl)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}butanoic acid · in 1 record
Experiment against prediction
- 9BNJ chain B against the predicted model P28796: TM-score 1.00, RMSD 0.44 Å
- 8V6P chain C against the predicted model P28796: TM-score 1.00, RMSD 0.49 Å
- 8V4A chain C against the predicted model P28796: TM-score 1.00, RMSD 0.56 Å
- 9BNJ chain C against the predicted model P28796: TM-score 1.00, RMSD 0.54 Å
- 1AX4 chain A against the predicted model P28796: TM-score 1.00, RMSD 0.55 Å
- 1AX4 chain A against the predicted model P28796: TM-score 1.00, RMSD 0.55 Å
- 5W1B chain A against the predicted model P28796: TM-score 0.99, RMSD 0.55 Å
- 9BNJ chain D against the predicted model P28796: TM-score 0.99, RMSD 0.75 Å
- 9BNJ chain A against the predicted model P28796: TM-score 0.99, RMSD 0.97 Å
- 8V6P chain D against the predicted model P28796: TM-score 0.98, RMSD 1.04 Å
Elsewhere
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