UniProt P28749
Retinoblastoma-like protein 1 (P28749)
Retinoblastoma-like protein 1 (UniProt P28749): 18 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 48 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P28749
- Protein
- Retinoblastoma-like protein 1
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 48 · 4 records with a druggable one
Structures
19 records of P28749 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H28 | CDK2/CyclinA in complex with an 11-residue recruitment peptide from p107 | x-ray diffraction | E, F | — | — |
| 1H28 | CDK2/CYCLIN a in complex with an 11-residue recruitment peptide from P107 | x-ray diffraction | E, F | — | — |
| 4YOO | p107 pocket domain in complex with LIN52 P29A peptide | x-ray diffraction | A | SO4 | 2 (best 0.44) |
| 4YOO | P107 pocket domain in complex with LIN52 P29A peptide | x-ray diffraction | A | SO4 | 2 (best 0.44) |
| 4YOS | p107 pocket domain complexed with LIN52 peptide | x-ray diffraction | A | SO4 | 2 (best 0.42) |
| 4YOS | P107 pocket domain complexed with LIN52 peptide | x-ray diffraction | A | SO4 | 2 (best 0.42) |
| 4YOZ | p107 pocket domain in complex with HPV E7 peptide | x-ray diffraction | A | SO4 | 2 (best 0.43) |
| 4YOZ | P107 pocket domain in complex with HPV E7 peptide | x-ray diffraction | A | SO4 | 2 (best 0.43) |
| 5TUV | Crystal structure of the E2F5-DP1-p107 ternary complex | x-ray diffraction | C, F | — | 2 (best 0.60) |
| 5TUV | Crystal structure of the E2F5-DP1-P107 ternary complex | x-ray diffraction | C, F | — | — |
| 7SMC | p107 pocket domain complexed with ARID4A peptide | x-ray diffraction | A, C | SO4 | 5 (best 0.73) |
| 7SMC | P107 pocket domain complexed with ARID4A peptide | x-ray diffraction | A, C | SO4 | — |
| 7SMD | p107 pocket domain complexed with EID1 peptide | x-ray diffraction | A | SO4 | 2 (best 0.40) |
| 7SMD | P107 pocket domain complexed with EID1 peptide | x-ray diffraction | A | SO4 | — |
| 7SME | p107 pocket domain complexed with HDAC1 peptide | x-ray diffraction | A | SO4 | 2 (best 0.41) |
| 7SME | P107 pocket domain complexed with HDAC1 peptide | x-ray diffraction | A | SO4 | — |
| 7SMF | p107 pocket domain complexed with mutated HDAC1-3X peptide | x-ray diffraction | A, C | SO4 | 10 (best 0.74) |
| 7SMF | P107 pocket domain complexed with mutated HDAC1-3X peptide | x-ray diffraction | A, C | SO4 | — |
| P28749 | AlphaFold monomer V2.0 prediction for retinoblastoma-like protein 1 (P28749) | predicted | A | — | 15 (best 0.81) |
Ligands
- SO4 · Sulfate ion · in 14 records
Experiment against prediction
- 7SMF chain A against the predicted model P28749: TM-score 0.99, RMSD 0.92 Å
- 7SMF chain A against the predicted model P28749: TM-score 0.99, RMSD 0.92 Å
- 7SMD chain A against the predicted model P28749: TM-score 0.99, RMSD 0.91 Å
- 7SMD chain A against the predicted model P28749: TM-score 0.99, RMSD 0.91 Å
- 7SMC chain A against the predicted model P28749: TM-score 0.99, RMSD 0.93 Å
- 7SMC chain A against the predicted model P28749: TM-score 0.99, RMSD 0.93 Å
- 7SME chain A against the predicted model P28749: TM-score 0.98, RMSD 0.94 Å
- 7SME chain A against the predicted model P28749: TM-score 0.98, RMSD 0.94 Å
- 7SMC chain C against the predicted model P28749: TM-score 0.98, RMSD 1.15 Å
- 7SMC chain C against the predicted model P28749: TM-score 0.98, RMSD 1.15 Å
Elsewhere
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