UniProt P28496
Ceramide synthase LAC1 (P28496)
Ceramide synthase LAC1 (UniProt P28496), EC 2.3.1.297: 3 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P28496
- Protein
- Ceramide synthase LAC1
- EC
- 2.3.1.297
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 23 · 3 records with a druggable one
Structures
4 records of P28496 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8IZD | Cryo-EM structure of the C26-CoA-bound Lac1-Lip1 complex | electron microscopy | A, C | 6PL, 9NY | 8 (best 0.81) |
| 8QTR | Cryo-EM structure of the FB-bound yeast Ceramide Synthase | electron microscopy | B | WXE, 3PE, 7PO, PIJ | 6 (best 0.79) |
| 8Y2M | Cryo-EM structure of the FB1-bound Lac1-Lip1 complex | electron microscopy | A, C | 6PL, A1D5V, 7PO | 9 (best 0.81) |
| P28496 | AlphaFold monomer V2.0 prediction for ceramide synthase LAC1 (P28496) | predicted | A | — | — |
Ligands
- 6PL · (4S,7R)-4-hydroxy-N,N,N-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide · in 2 records
- 7PO · hexacosanoic acid · in 2 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 1 record
- 9NY · Hexacosanoyl-CoA · in 1 record
- A1D5V · (2~{R})-2-[2-[(5~{R},6~{R},7~{S},9~{S},11~{R},16~{R},18~{S},19~{S})-19-azanyl-6-[(3~{R})-3-carboxy-5-oxidanyl-5-oxidanylidene-pentanoyl]oxy-5,9-dimethyl-11,16,18-tris(oxidanyl)icosan-7-yl]oxy-2-oxidanylidene-ethyl]butanedioic acid · in 1 record
- PIJ · [(2S)-1-hexadecanoyloxy-3-[hydroxy-[(2S,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] heptadecanoate · in 1 record
- WXE · Macrofusine · in 1 record
Experiment against prediction
- 8QTR chain B against the predicted model P28496: TM-score 0.97, RMSD 1.16 Å
- 8IZD chain C against the predicted model P28496: TM-score 0.97, RMSD 1.18 Å
- 8IZD chain A against the predicted model P28496: TM-score 0.97, RMSD 1.18 Å
- 8Y2M chain C against the predicted model P28496: TM-score 0.97, RMSD 1.20 Å
- 8Y2M chain A against the predicted model P28496: TM-score 0.97, RMSD 1.20 Å
Elsewhere
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